Skip to main content
PMC home page
Immunology logoLink to Immunology
. 1974 May;26(5):893–900.

The long-term antibody response of New Zealand Black mice to sheep red blood cells

Elisabeth A S Elkerbout, W Hijmans
PMCID: PMC1423245  PMID: 4605286

Abstract

Long-term IgM and IgG responses to sheep red blood cells (SRBC) were determined in New Zealand Black (NZB) mice, using the plaque technique. As compared with other strains a prolonged spleen plaque-forming cell (PFC) response was found in young and old NZB mice. This phenomenon was found in the primary as well as in the secondary response and concerned IgM as well as IgG production. These observations are discussed in relation to the production of IgG antibodies of a low avidity.

Full text

PDF
898

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BURNET F. M., HOLMES M. C. Immunological function of thymus and bursa of Fabricius. Thymus lesions in an auto-immune disease of mice. Nature. 1962 Apr 14;194:146–147. doi: 10.1038/194146a0. [DOI] [PubMed] [Google Scholar]
  2. Baum J. Increased 7S antibody response to sheep erythrocytes in the 2-month-old NZB mouse. Clin Exp Immunol. 1969 Sep;5(3):251–263. [PMC free article] [PubMed] [Google Scholar]
  3. Cerottini J. C., Lambert P. H., Dixon F. J. Comparison of the immune responsiveness of NZB and NZB X NZW F1 hybrid mice with that of other strains of mice. J Exp Med. 1969 Nov 1;130(5):1093–1105. doi: 10.1084/jem.130.5.1093. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cunningham A. J. A method of increased sensitivity for detecting single antibody-forming cells. Nature. 1965 Sep 4;207(5001):1106–1107. doi: 10.1038/2071106a0. [DOI] [PubMed] [Google Scholar]
  5. Cunningham A. J., Szenberg A. Further improvements in the plaque technique for detecting single antibody-forming cells. Immunology. 1968 Apr;14(4):599–600. [PMC free article] [PubMed] [Google Scholar]
  6. Diener E. The immune response in NZB and NZB x C3H F1-hybrid mice as measured by the haemolysin plaque technique. Int Arch Allergy Appl Immunol. 1966;30(2):120–131. doi: 10.1159/000229801. [DOI] [PubMed] [Google Scholar]
  7. Evans M. M., Williamson W. G., Irvine W. J. The appearance of immunological competence at an early age in New Zealand black mice. Clin Exp Immunol. 1968 Jun;3(5):375–383. [PMC free article] [PubMed] [Google Scholar]
  8. Henry C., Jerne N. K. Competition of 19S and 7S antigen receptors in the regulation of the primary immune response. J Exp Med. 1968 Jul 1;128(1):133–152. doi: 10.1084/jem.128.1.133. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hijmans W., Radema H., van Es L., Feltkamp T. E., van Loghem J. J., Schaap O. L. Cryoglobulins in New Zealand Black mice. Clin Exp Immunol. 1969 Feb;4(2):227–239. [PMC free article] [PubMed] [Google Scholar]
  10. Holborow E. J., Denman A. M. Autoimmune disease in inbred mice. Clin Exp Immunol. 1967 Dec;2(Suppl):761–767. [PMC free article] [PubMed] [Google Scholar]
  11. MUNOZ J. Production in mice of large volumes of ascites fluid containing antibodies. Proc Soc Exp Biol Med. 1957 Aug-Sep;95(4):757–759. doi: 10.3181/00379727-95-23355. [DOI] [PubMed] [Google Scholar]
  12. Mellors R. C., Shirai T., Aoki T., Huebner R. J., Krawczynski K. Wild-type Gross leukemia virus and the pathogenesis of the glomerulonephritis of New Zealand mice. J Exp Med. 1971 Jan 1;133(1):113–132. doi: 10.1084/jem.133.1.113. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Morton J. I., Siegel B. V. Response of NZB mice to foreign antigen and development of autoimmune disease. J Reticuloendothel Soc. 1969 Feb;6(1):78–93. [PubMed] [Google Scholar]
  14. Raverman I. M., Slesinski J. Study of autoimmune disease in New Zealand mice. 3. Mechanisms underlying hemolytic anemia of NZB mice. J Invest Dermatol. 1968 Oct;51(4):274–279. doi: 10.1038/jid.1968.127. [DOI] [PubMed] [Google Scholar]
  15. Staples P. J., Steinberg A. D., Talal N. Induction of immunologic tolerance in older New Zealand mice repopulated with young spleen, bone marrow, or thymus. J Exp Med. 1970 Jun 1;131(6):1223–1238. doi: 10.1084/jem.131.6.1223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Walker J. G., Siskind G. W. Studies on the control of antibody synthesis. Effect of antibody affinity upon its ability to suppress antibody formation. Immunology. 1968 Jan;14(1):21–28. [PMC free article] [PubMed] [Google Scholar]
  17. de Vries M. J., Hijmans W. Pathological changes of thymic epithelial cells and autoimmune disease in NZB, NZW and (NZB x NZW)F1 mice. Immunology. 1967 Feb;12(2):179–196. [PMC free article] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES