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. 1963 Sep;6(5):484–498.

A Factor Capable of Increasing Vascular Permeability Present in Lymph Node Cells

A Possible Mediator of the Delayed Reaction

D A Willoughby, Barbara Boughton, H O Schild
PMCID: PMC1423277  PMID: 14069726

Abstract

A soluble extract from guinea-pig lymph node cells (LPF) has been found to increase vascular permeability in the skin of the rat. The active substance has been differentiated from histamine, 5-hydroxytryptamine, bradykinin, substance P, kallikrein and the globulin permeability factors from rat and guinea-pig serum by means of parallel quantitative assays. LPF was present in both sensitized and non-sensitized guinea-pig lymph node cells and in lymph node cells from rats and mice. LPF also increased vascular permeability in the skin of guinea-pigs, mice and rabbits. The possible importance of this factor in the mechanism of the delayed reactions is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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