Skip to main content
PMC home page
Immunology logoLink to Immunology
. 1963 Nov;6(6):592–601.

Ontogenesis of Immunity to Erythrocyte Antigens in the Chick

J B Solomon, D F Tucker
PMCID: PMC1423334  PMID: 14088897

Abstract

Erythrocytes labelled with chromium51 were injected into embryos and young chicks and a similar challenge given soon after the majority of the initial dose had been eliminated. While tolerance was the typical response in embryos and chicks up to 3 days of age, immunity could be induced in most chicks from this time onwards. The intensity of the immune response increased rapidly until the 12th day of age. No maternal antibody could be detected. Pretreatment of the embryo with testosterone impaired the immune response of 14-day-old chicks.

Full text

PDF
593

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BILLINGHAM R. E., BRENT L., MEDAWAR P. B. Tolerance of red cell antigens and transplantation immunity in chickens. Experientia. 1955 Nov 15;11(11):444–444. doi: 10.1007/BF02172551. [DOI] [PubMed] [Google Scholar]
  2. BUXTON A. Antibody production in avian embryos and young chicks. J Gen Microbiol. 1954 Jun;10(3):398–410. doi: 10.1099/00221287-10-3-398. [DOI] [PubMed] [Google Scholar]
  3. DRURY A. N., TUCKER E. M. The relationship between natural and immune haemolysins and incompatibility of 51Cr labelled red cells in the sheep. Immunology. 1958 Jul;1(3):204–216. [PMC free article] [PubMed] [Google Scholar]
  4. GLICK B. The influence of dipping eggs in male hormone solutions on lymphatic tissue and antibody response of chickens. Endocrinology. 1961 Nov;69:984–985. doi: 10.1210/endo-69-5-984. [DOI] [PubMed] [Google Scholar]
  5. HASEK M. Tolerance phenomena in birds. Proc R Soc Lond B Biol Sci. 1956 Nov 13;146(922):67–77. doi: 10.1098/rspb.1956.0072. [DOI] [PubMed] [Google Scholar]
  6. HORT J., HASEK M., KNIZETOVA F. Further immunological analysis of chicken embryonic parabionts. Folia Biol (Praha) 1961 Oct;7:301–308. [PubMed] [Google Scholar]
  7. HOWARD J. G., MICHIE D. Induction of transplantation immunity in the newborn mouse. Transplant Bull. 1962 Jan;29:1–6. [PubMed] [Google Scholar]
  8. KALMUTZ S. E. Antibody production in the opossum embryo. Nature. 1962 Mar 3;193:851–853. doi: 10.1038/193851a0. [DOI] [PubMed] [Google Scholar]
  9. MITCHISON N. A. Tolerance of erythrocytes in poultry: loss and abolition. Immunology. 1962 May;5:359–369. [PMC free article] [PubMed] [Google Scholar]
  10. MITCHISON N. A. Tolerance of erythrocytes in poultry:induction and specificity. Immunology. 1962 May;5:341–358. [PMC free article] [PubMed] [Google Scholar]
  11. MUELLER A. P., WOLFE H. R., MEYER R. K. Precipitin production in chickens. XXI. Antibody production in bursectomized chickens and in chickens injected with 19-nortestosterone on the fifth day of incubasion. J Immunol. 1960 Aug;85:172–179. [PubMed] [Google Scholar]
  12. SCHINCKEL P. G., FERGUSON K. A. Skin transplantation in the foetal lamb. Aust J Biol Sci. 1953 Aug;6(3):533–546. doi: 10.1071/bi9530533. [DOI] [PubMed] [Google Scholar]
  13. SIMONSEN M. The impact on the developing embryo and newborn animal of adult homologous cells. Acta Pathol Microbiol Scand. 1957;40(6):480–500. [PubMed] [Google Scholar]
  14. SMITH L. H., ODELL T. T., Jr, CALDWELL B. Life span of rat erythrocytes as determined by Cr51 and differential agglutination methods. Proc Soc Exp Biol Med. 1959 Jan;100(1):29–31. doi: 10.3181/00379727-100-24512. [DOI] [PubMed] [Google Scholar]
  15. SOLOMON J. B. The onset and maturation of the graft versus host reaction in chickens. J Embryol Exp Morphol. 1961 Sep;9:355–369. [PubMed] [Google Scholar]
  16. THORBECKE G. J., SISKIND G. W., GOLDBERGER N. The induction in mice of sensitization and immunological unresponsiveness by neonatal injection of bovine gamma-globulin. J Immunol. 1961 Aug;87:147–152. [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES