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. 1965 Oct;9(4):303–309.

The effect of decomplementation on delayed-type hypersensitive reactions to a conjugated antigen in rats

Thérèse Neveu, G Biozzi
PMCID: PMC1423600  PMID: 4158582

Abstract

A method has been described for quantitative measurement of the intensity of cutaneous delayed hypersensitive reactions in rats. This method is based on the measurement of the weight of skin infiltration at the site of cutaneous reaction.

In vivo decomplementation of rats with antigen—antibody complexes or aggregated γ-globulin is accompanied by a decrease in delayed hypersensitivity responsiveness.

When the level of serum complement is reduced by 90 per cent delayed hypersensitive reactions are completely suppressed.

The results presented, although suggestive, do not provide a definite proof of the role of complement in the development of delayed hypersensitive reactions in the skin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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