Abstract
In outbred guinea-pigs with a low level of hypersensitivity to hen egg albumin (HEA) at a time when circulating antibody was not detectable, unaggregated HEA in extracutaneous tissues was rapidly lost from the injection site and did not elicit lesions of delayed hypersensitivity. Aggregated HEA, however, was retained at the depot site and produced lesions in the bladders of similarly prepared guinea-pigs. In Hartley guinea-pigs with a high level of hypersensitivity, as measured by skin reactions, unaggregated HEA, though rapidly dissipated from depot sites, elicited lesions in the bladder. Aggregated HEA, though retained at injection sites, did not produced reactions of delayed hypersensitivity in kidney, testis and muscle. The inflammation of delayed hypersensitivity did not influence the disappearance rate of labelled HEA from the lesion, while the inflammation of an Arthus response was associated with retention of labelled antigen at the injection site.
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- COE J. E., SALVIN S. B. THE IMMUNE RESPONSE IN THE PRESENCE OF DELAYED HYPERSENSITIVITY OF CIRCULATING ANTIBODY. J Immunol. 1964 Sep;93:495–510. [PubMed] [Google Scholar]
- GORDON J., ROSE B., SEHON A. H. Detection of non-precipitating antibodies in sera of individuals allergic to ragweed pollen by an in vitro method. J Exp Med. 1958 Jul 1;108(1):37–51. doi: 10.1084/jem.108.1.37. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ISHIZAKA K., ISHIZAKA T. Biologic activity of aggregated gamma-globulin. II. A study of various methods for aggregation and species differences. J Immunol. 1960 Aug;85:163–171. [PubMed] [Google Scholar]
- KORNGOLD L., STAHLY G. L., DODD M. C., MYERS W. G. The comparative retention of antigen in the skin of immune and normal rabbits as determined with egg albumin labelled with radioactive iodine. J Immunol. 1953 Apr;70(4):345–351. [PubMed] [Google Scholar]
- LONG D. A. The fate of 131 I-labelled diphtheria toxin and toxoid in the skin of immune and allergic guinea-pigs. J Hyg (Lond) 1959 Jun;57(2):227–234. doi: 10.1017/s0022172400020076. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WEIGLE W. O., DIXON F. J. The antibody response of lymph node cells transferred to tolerant recipients. J Immunol. 1959 Jun;82(6):516–519. [PubMed] [Google Scholar]