Abstract
Rabbits thymectomized between 12 and 36 hours after birth subsequently show reduced levels of circulating lymphocytes together with a lowered immunological response to human γ-globulin. These effects of thymectomy can, to a large extent, be prevented by means of intraperitoneal auto-transplants of thymus in a Millipore diffusion chamber. It appears possible that the epithelial-reticular cells of the transplant persist in the diffusion chamber and elaborate a humoral factor, or factors, which take part in the maturation of antibody-producing cells.
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- AISENBERG A. C., WILKES B. PARTIAL IMMUNOLOGICAL RESTORATION OF NEONATALLY THYMECTOMIZED RATS WITH THYMUS-CONTAINING DIFFUSION CHAMBERS. Nature. 1965 Feb 13;205:716–717. doi: 10.1038/205716a0. [DOI] [PubMed] [Google Scholar]
- BOYDEN S. V., SORKIN E. A study of antigens active in the tannic acid hemagglutination test present in filtrates of culture of Mycobacterium tuberculosis. J Immunol. 1955 Jul;75(1):15–21. [PubMed] [Google Scholar]
- HAYS E. F. GROWTH AND MORPHOLOGY OF MOUSE LYMPHOMA CELLS IN DIFFUSION CHAMBERS. Proc Soc Exp Biol Med. 1964 Oct;117:45–50. doi: 10.3181/00379727-117-29492. [DOI] [PubMed] [Google Scholar]
- HOLUB M. Antibody production by lymphocytes after in vitro contact with bacterial antigen and transfer to new-born rabbits. Nature. 1958 Jan 11;181(4602):122–122. doi: 10.1038/181122a0. [DOI] [PubMed] [Google Scholar]
- LAW L. W., TRAININ N., LEVEY R. H., BARTH W. F. HUMORAL THYMIC FACTOR IN MICE: FURTHER EVIDENCE. Science. 1964 Mar 6;143(3610):1049–1051. doi: 10.1126/science.143.3610.1049. [DOI] [PubMed] [Google Scholar]
- LEVEY R. H., TRAININ N., LAW L. W. EVIDENCE FOR FUNCTION OF THYMIC TISSUE IN DIFFUSION CHAMBERS IMPLANTED IN NEONATALLY THYMECTOMIZED MICE. PRELIMINARY REPORT. J Natl Cancer Inst. 1963 Aug;31:199–217. [PubMed] [Google Scholar]
- OSOBA D., MILLER J. F. THE LYMPHOD TISSUES AND IMMUNE RESPONSES OF NEONATALLY THYMECTOMIZED MICE BEARING THYMUS TISSUE IN MILLIPORE DIFFUSION CHAMBERS. J Exp Med. 1964 Jan 1;119:177–194. doi: 10.1084/jem.119.1.177. [DOI] [PMC free article] [PubMed] [Google Scholar]