Skip to main content
PMC home page
Immunology logoLink to Immunology
. 1966 Jun;10(6):507–515.

On the specificity of autoantibodies present in colon cancer patients

Sabine Von Kleist, P Burtin
PMCID: PMC1423742  PMID: 4958052

Abstract

223 sera of patients having a colonic cancer or other diseases were examined for the presence of antibodies agglutinating tanned sheep erythrocytes coated with saline extracts of human colonic cancers. Some patients' sera were also investigated for precipitating antibodies. Many positive results were found, mainly but not only, in colonic cancer patients' sera. By absorption studies the antibodies found in these sera have been shown to be directed against an antigen present not only in the tumours but also in normal and foetal tissues as well as in the microsomal fraction of the intestine. The chemical nature of the antigen is still under investigation.

Full text

PDF
515

Images in this article

512-1FIG. 2
on p.512-1
512-1FIG. 3
on p.512-1
512-1FIG. 4
on p.512-1

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOYDEN S. V. The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. J Exp Med. 1951 Feb;93(2):107–120. doi: 10.1084/jem.93.2.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BROBERGER O., PERLMANN P. Autoantibodies in human ulcerative colitis. J Exp Med. 1959 Nov 1;110:657–674. doi: 10.1084/jem.110.5.657. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. FINNEY J. W., BYERS E. H., WILSON R. H. Studies in tumor autoimmunity. Cancer Res. 1960 Apr;20:351–356. [PubMed] [Google Scholar]
  4. GOLDGRABER M. B., HUMPHREYS E. M., KIRSNER J. B., PALMER W. L. Carcinoma and ulcerative colitis, a clinical-pathologic study. I. Cancer deaths. Gastroenterology. 1958 May;34(5):809–839. [PubMed] [Google Scholar]
  5. GOLDGRABER M. B., KIRSNER J. B. CARCINOMA OF THE COLON IN ULCERATIVE COLITIS. Cancer. 1964 May;17:657–665. doi: 10.1002/1097-0142(196405)17:5<657::aid-cncr2820170515>3.0.co;2-7. [DOI] [PubMed] [Google Scholar]
  6. GRABAR P., WILLIAMS C. A. Méthode permettant l'étude conjuguée des proprietés électrophorétiques et immunochimiques d'un mélange de protéines; application au sérum sanguin. Biochim Biophys Acta. 1953 Jan;10(1):193–194. doi: 10.1016/0006-3002(53)90233-9. [DOI] [PubMed] [Google Scholar]
  7. GRAHAM J. B., GRAHAM R. M. Antibodies elicited by cancer in patients. Cancer. 1955 Mar-Apr;8(2):409–416. doi: 10.1002/1097-0142(1955)8:2<409::aid-cncr2820080221>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]
  8. ITOH T., SOUTHAM C. M. ISOANTIBODIES TO HUMAN CANCER CELLS IN CANCER PATIENTS FOLLOWING CANCER HOMOTRANSPLANTS. J Immunol. 1964 Dec;93:926–936. [PubMed] [Google Scholar]
  9. KONDO T., ICHIHASHI H. [INDUCTION OF METASTASES BY TREATMENT WITH CARCINOSTATIC AGENTS. II. DEPRESSION OF HOST RESISTANCE AND ANTIBODY PRODUCTION]. Gan. 1964 Oct;55:403–410. [PubMed] [Google Scholar]
  10. KORNGOLD L., PRESSMAN D. The localization of antilymphosarcoma antibodies in the Murphy lymphosarcoma of the rat. Cancer Res. 1954 Feb;14(2):96–99. [PubMed] [Google Scholar]
  11. Loisillier F., Buffe D., Tan K. B., Burtin P., Grabar P. Etude immunologique des épithéliomas mammaires humains. Ann Inst Pasteur (Paris) 1965 Jul;109(1):1–21. [PubMed] [Google Scholar]
  12. OUCHTERLONY O. Diffusion-in-gel methods for immunological analysis. Prog Allergy. 1958;5:1–78. [PubMed] [Google Scholar]
  13. PEREZ-CUADRADO S., RACE G. J., HABERMAN S. FLUORESCENT ANTIBODIES TO HUMAN CANCER-SPECIFIC DNA AND NUCLEAR PROTEINS. Cancer. 1965 Feb;18:193–200. doi: 10.1002/1097-0142(196502)18:2<193::aid-cncr2820180210>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
  14. ROSE N. R., SHULMAN S., WITEBSKY E. Studies of normal and malignant tissue antigens. Cancer Res. 1956 Oct;16(9):831–841. [PubMed] [Google Scholar]
  15. ZILBER L. A. Specific tumor antigens. Adv Cancer Res. 1958;5:291–329. doi: 10.1016/s0065-230x(08)60414-5. [DOI] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES