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. 1966 Sep;11(3):229–241.

The role of mycobacteria and silica in the immunological response of the guinea-pig

P C Wilkinson, R G White
PMCID: PMC1423776  PMID: 4162436

Abstract

The relationships between the development of a local epithelioid or macrophage granulomatous tissue reaction, of delayed-type hypersensitivity and of biosynthesis of γ2-immunoglobulin have been explored in guinea-pigs injected with antigen mixtures containing aluminium silicate (bentonite) particles in saline suspension or containing whole mycobacterial cells or their extracted peptidoglycolipids in water-in-oil emulsions.

Bentonite was found to be effective in inducing local granulomatous tissue proliferation and the formation of γ2-immunoglobulin. In the same animals, in a minority of circumstances, bentonite was capable of inducing delayed-type hypersensitivity to the accompanying protein antigen. Thus bentonite could reproduce, in these three respects, the specific immunological effects produced by mycobacteria or their extracted peptidoglycolipids. By the use of prior injection of the homologous antigen, partial blockage of the production of delayed-type hypersensitivity following subsequent injection of the antigen in Freund's complete adjuvant could be effected. At the same time changes occurred in granuloma formation and biosynthesis of γ2-immunoglobulin. The reasons for the apparent linkage of these events are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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