Skip to main content
PMC home page
Immunology logoLink to Immunology
. 1966 Sep;11(3):175–183.

The depression of the immune response by serum protein fractions

F H Sims, Jean W Freeman
PMCID: PMC1423786  PMID: 4162433

Abstract

A number of serum protein fractions were tested for their ability to suppress the immune response of rats injected with washed sheep cells. Significant depression of the immune response was produced by human serum proteins, and by bovine α-globulin fractions. The mechanism of this effect is at present not clear.

Full text

PDF
179

Images in this article

179FIG. 2
on p.179

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BERGLUND K. Hemolysin response in the rat after a single intraperitoneal injection of sheep erythrocytes. Acta Pathol Microbiol Scand. 1956;38(3):220–230. doi: 10.1111/j.1699-0463.1956.tb03170.x. [DOI] [PubMed] [Google Scholar]
  2. KAMRIN B. B. Studies on the healing of successful skin homografts in albino rats. Ann N Y Acad Sci. 1960 May 31;187:323–351. doi: 10.1111/j.1749-6632.1960.tb23204.x. [DOI] [PubMed] [Google Scholar]
  3. KAMRIN B. B. Successful skin bomografts in mature non-littermate rats treated with fractions containing alpha-globulins. Proc Soc Exp Biol Med. 1959 Jan;100(1):58–61. doi: 10.3181/00379727-100-24522. [DOI] [PubMed] [Google Scholar]
  4. KAMRIN B. B. The use of globulins as a means of inducing acquired tolerance to parabiotic union. Ann N Y Acad Sci. 1958 Oct 7;73(3):848–861. doi: 10.1111/j.1749-6632.1959.tb40865.x. [DOI] [PubMed] [Google Scholar]
  5. LIACOPOULOS P. SUPPRESSION OF IMMUNOLOGICAL RESPONSES DURING THE INDUCTION OF IMMUNE PARALYSIS WITH UNRELATED ANTIGENS. Tex Rep Biol Med. 1965;23:63–80. [PubMed] [Google Scholar]
  6. MOWBRAY J. F. Ability of large doses of an alpha-2 plasma protein fraction to inhibit antibody production. Immunology. 1963 May;6:217–225. [PMC free article] [PubMed] [Google Scholar]
  7. MOWBRAY J. F. Effect of large doses of an alpha2-glycoprotein fraction on the survival of rat skin homografts. Transplantation. 1963 Jan;1:15–20. doi: 10.1097/00007890-196301010-00003. [DOI] [PubMed] [Google Scholar]
  8. MOWBRAY J. F. Effect on antibody production of injection of an alpha2-protein fraction. Nature. 1963 Mar 9;197:1019–1019. doi: 10.1038/1971019a0. [DOI] [PubMed] [Google Scholar]
  10. THOMPSON R., FISHEL C. W. INHIBITION OF ANTIBODY FORMATION BY HOMOLOGOUS TISSUE FACTORS. J Immunol. 1965 Mar;94:379–384. [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES