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. 1982 Aug;14(2):247–256. doi: 10.1111/j.1365-2125.1982.tb01969.x

OPT: a package of computer programs for parameter optimisation in clinical pharmacokinetics.

A W Kelman, B Whiting, S M Bryson
PMCID: PMC1427763  PMID: 7104175

Abstract

1 OPT is a series of computer programs designed to assist dose optimisation for individual patients. It is based on Bayesian Statistical Theory and Maximum Likelihood Estimation. 2 OPT uses prior information on the distribution of population pharmacokinetic parameters and plasma drug concentration measurements to obtain the "most likely' set of parameters for the individual. 3 Complex dosage regimes and non-steady state conditions can be handled. 4 OPT is designed for use in a Clinical Pharmacokinetics Laboratory where informed interpretation of results is essential. 5 The drugs for which the system is currently available include theophylline, digoxin, lignocaine, disopyramide, gentamicin and phenytoin (steady state data only).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bryson S. M., Cairns C. J., Whiting B. Disopyramide pharmacokinetics during recovery from myocardial infarction. Br J Clin Pharmacol. 1982 Mar;13(3):417–421. doi: 10.1111/j.1365-2125.1982.tb01395.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bryson S. M., Whiting B., Lawrence J. R. Disopyramide serum and pharmacologic effect kinetics applied to the assessment of bioavailability. Br J Clin Pharmacol. 1978 Nov;6(5):409–419. doi: 10.1111/j.1365-2125.1978.tb04605.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Iisalo E., Dahl M., Sundqvist H. Serum digoxin in adults and children. Int J Clin Pharmacol. 1973 Apr;7(2):219–222. [PubMed] [Google Scholar]
  4. Jusko W. J., Gardner M. J., Mangione A., Schentag J. J., Koup J. R., Vance J. W. Factors affecting theophylline clearances: age, tobacco, marijuana, cirrhosis, congestive heart failure, obesity, oral contraceptives, benzodiazepines, barbiturates, and ethanol. J Pharm Sci. 1979 Nov;68(11):1358–1366. doi: 10.1002/jps.2600681106. [DOI] [PubMed] [Google Scholar]
  5. Kelman A. W., Sumner D. J., Whiting B. The prediction of individual systolic time interval v heart rate regression equations. Br J Clin Pharmacol. 1981 Jul;12(1):21–30. doi: 10.1111/j.1365-2125.1981.tb01850.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Sheiner L. B., Beal S., Rosenberg B., Marathe V. V. Forecasting individual pharmacokinetics. Clin Pharmacol Ther. 1979 Sep;26(3):294–305. doi: 10.1002/cpt1979263294. [DOI] [PubMed] [Google Scholar]
  7. Sheiner L. B., Halkin H., Peck C., Rosenberg B., Melmon K. L. Improved computer-assisted digoxin therapy. A method using feedback of measured serum digoxin concentrations. Ann Intern Med. 1975 May;82(5):619–627. doi: 10.7326/0003-4819-82-5-619. [DOI] [PubMed] [Google Scholar]
  8. Sheiner L. B., Rosenberg B., Marathe V. V. Estimation of population characteristics of pharmacokinetic parameters from routine clinical data. J Pharmacokinet Biopharm. 1977 Oct;5(5):445–479. doi: 10.1007/BF01061728. [DOI] [PubMed] [Google Scholar]
  9. Shen D. D., Cunningham J. L., Shudo I., Azarnoff D. L. Disposition kinetics of disopyramide in patients with renal insufficiency. Biopharm Drug Dispos. 1980 Jan-Mar;1(3):133–140. doi: 10.1002/bdd.2510010308. [DOI] [PubMed] [Google Scholar]
  10. Vozeh S., Muir K. T., Sheiner L. B., Follath F. Predicting individual phenytoin dosage. J Pharmacokinet Biopharm. 1981 Apr;9(2):131–146. doi: 10.1007/BF01068078. [DOI] [PubMed] [Google Scholar]

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