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. 1983 Aug;16(2):167–174. doi: 10.1111/j.1365-2125.1983.tb04981.x

An assessment of physiological finger tremor as an indicator of beta-adrenoceptor function.

J M Arnold, D G McDevitt
PMCID: PMC1427990  PMID: 6311233

Abstract

Physiological finger tremor has been assessed as an indicator of beta-adrenoceptor function. Tremor was not correlated with the sex, age, weight or height of the subjects and was stable over 5 min when the hand and fingers were held horizontally. It was not increased by mental arithmetic, the Valsalva manoeuvre or 3 min exercise. Satisfactory dose-response curves could be constructed for the isoprenaline enhanced increases in finger tremor. In six subjects, practolol 120 mg produced a small shift to the right of the isoprenaline dose-response curve for finger tremor (dose ratio 2.1) but propranolol 40 mg was seven times more effective (dose ratio 17.1). Physiological finger tremor appears to be a stable parameter which may be useful in the investigation of the selectivity of beta-adrenoceptor blocking drugs.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BROD J., FENCL V., HEJL Z., JIRKA J. Circulatory changes underlying blood pressure elevation during acute emotional stress (mental arithmetic) in normotensive and hypertensive subjects. Clin Sci. 1959 May;18:269–279. [PubMed] [Google Scholar]
  2. Briant R. H., Dollery C. T., Fenyvesi T., George C. F. Assessment of selective beta-adrenoceptor blockade in man. Br J Pharmacol. 1973 Sep;49(1):106–114. doi: 10.1111/j.1476-5381.1973.tb08272.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brick I., Hutchison K. J., McDevitt D. G., Roddie I. C., Shanks R. G. Comparison of the effects of I.C.I. 50172 and propranolol on the cardiovascular responses to adrenaline, isoprenaline and exercise. Br J Pharmacol. 1968 Sep;34(1):127–140. doi: 10.1111/j.1476-5381.1968.tb07956.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Christensen N. J., Brandsborg O. The relationship between plasma catecholamine concentration and pulse rate during exercise and standing. Eur J Clin Invest. 1973 Jul;3(4):299–306. doi: 10.1111/j.1365-2362.1973.tb00355.x. [DOI] [PubMed] [Google Scholar]
  5. Cleaveland C. R., Rangno R. E., Shand D. G. A standardized isoproterenol sensitivity test. The effects of sinus arrhythmia, atropine, and propranolol. Arch Intern Med. 1972 Jul;130(1):47–52. doi: 10.1001/archinte.130.1.47. [DOI] [PubMed] [Google Scholar]
  6. De Plaen J. F., Amery A., Reybrouck T. Comparative potency of atenolol and propranolol as beta-adrenergic blocking agents in man. Eur J Clin Pharmacol. 1976 Sep 30;10(5):297–303. doi: 10.1007/BF00565617. [DOI] [PubMed] [Google Scholar]
  7. Larsson S., Svedmyr N. Tremor caused by sympathomimetics is mediated by beta2-adrenoreceptors. Scand J Respir Dis. 1977;58(1):5–10. [PubMed] [Google Scholar]
  8. Lertora J. J., Mark A. L., Johannsen J., Wilson W. R., Abboud F. M. Selective beta-1 receptor blockade with oral practolol in man. A dose-related phenomenon. J Clin Invest. 1975 Sep;56(3):719–724. doi: 10.1172/JCI108143. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Marsden C. D., Foley T. H., Owen D. A., McAllister R. G. Peripheral beta-adrenergic receptors concerned with tremor. Clin Sci. 1967 Aug;33(1):53–65. [PubMed] [Google Scholar]
  10. McDevitt D. G., Brown H. C., Carruthers S. G., Shanks R. G. Influence of intrinsic sympathomimetic activity and cardioselectivity on beta adrenoceptor blockade. Clin Pharmacol Ther. 1977 May;21(5):556–566. doi: 10.1002/cpt1977215556. [DOI] [PubMed] [Google Scholar]
  11. McDevitt D. G. The assessment of beta-adrenoceptor blocking drugs in man. Br J Clin Pharmacol. 1977 Aug;4(4):413–425. doi: 10.1111/j.1365-2125.1977.tb00756.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Perucca E., Pickles H., Richens A. Effect of atenolol, metoprolol, and propranolol on isoproterenol-induced tremor and tachycardia in normal subjects. Clin Pharmacol Ther. 1981 Apr;29(4):425–433. doi: 10.1038/clpt.1981.59. [DOI] [PubMed] [Google Scholar]
  13. Pickles H., Perucca E., Fish A., Richens A. Propranolol and sotalol as antagonists of isoproterenol-enhanced physiologic tremor. Clin Pharmacol Ther. 1981 Sep;30(3):303–310. doi: 10.1038/clpt.1981.164. [DOI] [PubMed] [Google Scholar]
  14. Thiringer G., Svedmyr N. Evaluation of skeletal muscle tremor due to bronchodilator agents. Scand J Respir Dis. 1975 Aug;56(2):93–102. [PubMed] [Google Scholar]

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