Skip to main content
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1977 Apr;4(2):213–221. doi: 10.1111/j.1365-2125.1977.tb00697.x

Monitoring digoxin therapy: I. Plasma concentrations and an in vitro assay of tissue response.

J K Aronson, D G Grahame-Smith, K F Hallis, A Hibble, F Wigley
PMCID: PMC1429008  PMID: 861136

Abstract

1 An in vitro technique is described for measuring the uptake of 86Rb by human erythrocytes. 2 Fifteen patients were treated with digoxin for atrial fibrillation and other fast arrhythmias. 3 86Rb uptake by the patients' own red cells fell from pre-treatment values during digitalization. 4 The therapeutic response of patients with atrial fibrillation correlated better with the changes in 86Rb uptake than with plasma digoxin concentrations.

Full text

PDF
218

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aronson J. K., Grahame-Smith D. G. Monitoring digoxin therapy: II. Determinants of the apparent volume of distribution. Br J Clin Pharmacol. 1977 Apr;4(2):223–227. doi: 10.1111/j.1365-2125.1977.tb00698.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Astrup J. Sodium and potassium in human red cells: variations among centrifuged cells. Scand J Clin Lab Invest. 1974 May;33(3):231–237. doi: 10.1080/00365517409082491. [DOI] [PubMed] [Google Scholar]
  3. Bernstein J. C., Israel Y. Active transport of Rb86 in human red cells and rat brain slices. J Pharmacol Exp Ther. 1970 Aug;174(2):323–329. [PubMed] [Google Scholar]
  4. Blood B. E. Proceedings: The influence of low doses of ouabain and potassium ions on sheep Purkinje fibre contractility. J Physiol. 1975 Sep;251(1):69P–70P. [PubMed] [Google Scholar]
  5. Bluschke V., Bonn R., Greeff K. Increase in the (Na+ + K+)-ATPase activity in heart muscle after chronic treatment with digitoxin or potassium deficient diet. Eur J Pharmacol. 1976 May;37(1):189–191. doi: 10.1016/0014-2999(76)90021-2. [DOI] [PubMed] [Google Scholar]
  6. Boullin D. J., Woods H. F., Grimes R. P., Grahame-Smith D. G. Increased platelet aggregation responses to 5-hydroxytryptamine in patients taking chlorpromazine. Br J Clin Pharmacol. 1975 Feb;2(1):29–35. doi: 10.1111/j.1365-2125.1975.tb00468.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. CLIFFORD T. C., BEAUTYMAN W. Changes in the erythrocyte potassium in patients with cardiac failure treated with digitalis. Clin Chem. 1958 Aug;4(4):311–315. [PubMed] [Google Scholar]
  8. Cohen I., Daut J., Noble D. Proceedings: The influence of extracellular potassium ions on the action of ouabain on membrane currents in sheep Purkinje fibres. J Physiol. 1975 Jul;249(1):42P–43P. [PubMed] [Google Scholar]
  9. Curd J., Smith T. W., Jaton J. C., Haber E. The isolation of digoxin-specific antibody and its use in reversing the effects of digoxin. Proc Natl Acad Sci U S A. 1971 Oct;68(10):2401–2406. doi: 10.1073/pnas.68.10.2401. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Funder J., Wieth J. O. Combined effects of digitalis therapy and of plasma bicarbonate on human red cell socium and potassium. Scand J Clin Lab Invest. 1974 Oct;34(2):153–160. [PubMed] [Google Scholar]
  11. Hibble A. G., Grahame-Smith D. G. The plasma digoxin concentration, red cell rubidium 86 uptake and control of ventricular rate in patients being digitalized for artrial fibrilation. Clin Sci. 1972 Jan;42(1):3P–3P. doi: 10.1042/cs042003pa. [DOI] [PubMed] [Google Scholar]
  12. Hoeschen R. J., Cuddy T. E. Dose-response relation between therapeutic levels of serum digoxin and systolic time intervals. Am J Cardiol. 1975 Apr;35(4):469–472. doi: 10.1016/0002-9149(75)90828-0. [DOI] [PubMed] [Google Scholar]
  13. Härtel G., Kyllönen K., Merikallio E., Ojala K., Manninen V., Reissell P. Human serum and myocardium digoxin. Clin Pharmacol Ther. 1976 Feb;19(2):153–157. doi: 10.1002/cpt1976192153. [DOI] [PubMed] [Google Scholar]
  14. Ingelfinger J. A., Goldman P. The serum digitalis concentration--does it diagnose digitalis toxicity? N Engl J Med. 1976 Apr 15;294(16):867–870. doi: 10.1056/NEJM197604152941603. [DOI] [PubMed] [Google Scholar]
  15. Katz A. I., Lindheimer M. D. Renal sodium- and potassium-activated adenosine triphosphatase and sodium reabsorption in the hypothyroid rat. J Clin Invest. 1973 Apr;52(4):796–804. doi: 10.1172/JCI107243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Kettlewell M., Nowers A., White R. Effect of digoxin on human red blood cell electrolytes. Br J Pharmacol. 1972 Jan;44(1):165–167. doi: 10.1111/j.1476-5381.1972.tb07250.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. LOVE W. D., BURCH G. E. A comparison of potassium 42, rubidium 86, and cesium 134 as tracers of potassium in the study of cation metabolism of human erythrocytes in vitro. J Lab Clin Med. 1953 Mar;41(3):351–362. [PubMed] [Google Scholar]
  18. Redfors A. Plasma digoxin concentration--its relation to digoxin dosage and clinical effects in patients with atrial fibrillation. Br Heart J. 1972 Apr;34(4):383–391. doi: 10.1136/hrt.34.4.383. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. SCHATZMANN H. J. Herzglykoside als Hemmstoffe für den aktiven Kalium- und Natriumtransport durch die Erythrocytenmembran. Helv Physiol Pharmacol Acta. 1953;11(4):346–354. [PubMed] [Google Scholar]
  20. Schwartz A., Lindenmayer G. E., Allen J. C. The sodium-potassium adenosine triphosphatase: pharmacological, physiological and biochemical aspects. Pharmacol Rev. 1975 Mar;27(01):3–134. [PubMed] [Google Scholar]
  21. Smith T. W., Butler V. P., Jr, Haber E. Determination of therapeutic and toxic serum digoxin concentrations by radioimmunoassay. N Engl J Med. 1969 Nov 27;281(22):1212–1216. doi: 10.1056/NEJM196911272812203. [DOI] [PubMed] [Google Scholar]
  22. WELT L. G., SACHS J. R., MCMANUS T. J. AN ION TRANSPORT DEFECT IN ERYTHROCYTES FROM UREMIC PATIENTS. Trans Assoc Am Physicians. 1964;77:169–181. [PubMed] [Google Scholar]
  23. Weissler A. M., Schoenfeld C. D. Effect of digitalis on systolic time intervals in heart failure. Am J Med Sci. 1970 Jan;259(1):4–20. doi: 10.1097/00000441-197001000-00002. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES