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. 1977 Jun;4(3):275–281. doi: 10.1111/j.1365-2125.1977.tb00712.x

Indirect blood pressure and heart rate measured quickly without observer bias using a semi-automatic machine (auto-manometer)--response to isometric exercise in normal healthy males and its modification by beta-adrenoceptor blockade.

G Nyberg
PMCID: PMC1429074  PMID: 901695

Abstract

1 In a double-blind crossover study, six volunteers performed sustained handgrip at 50% of maximal voluntary contraction before and 90 min following oral administration of 0.25 and 100 mg metoprolol tartrate, a beta1 selective adrenoceptor blocking agent. Blood pressure and heart rate were measured with the Auto-Manometer, an electronic semi-automatic device based on the principles of the London School of Hygiene and Tropical Medicine sphygmomanometer. It eliminates observer and digital bias completely, and also records heart rate at the same time as blood pressure is recorded. 2 Resting heart rate fell 15% after 25 mg, 21% after 100 mg and was unchanged after placebo. Systolic blood pressure fell 6% on both doses and was unchanged on placebo. Diastolic pressure did not change with any of the doses. 3 At 1 min of handgrip, heart rate was significantly lower after 25 and 100 mg than before drug or after placebo. There was no difference between the blood pressure levels attained before or after any of the dose levels. The rise of heart rate tended to be somewhat dampened after 100 mg only. The rise in blood pressure was unchanged after any dose compared with before.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ablad B., Borg K. O., Carlsson E., EK L., Johnson G., Malmfors T., Regårdh C. G. A survey of the pharmacological properties of metoprolol in animals and man. Acta Pharmacol Toxicol (Copenh) 1975;36(Suppl 5):7–23. doi: 10.1111/j.1600-0773.1975.tb03318.x. [DOI] [PubMed] [Google Scholar]
  2. Doyle A. E. Use of beta-adrenoreceptor blocking drugs in hypertension. Drugs. 1974;8(6):422–431. doi: 10.2165/00003495-197408060-00006. [DOI] [PubMed] [Google Scholar]
  3. Ewing D. J., Irving J. B., Kerr F., Kirby B. J. Static exercise in untreated systemic hypertension. Br Heart J. 1973 Apr;35(4):413–421. doi: 10.1136/hrt.35.4.413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Forsberg S. A., Johnsson G. Hemodynamic effects of propranolol and H 56-28 in man--comparative study of two beta-adrenergic receptor antagonists. Acta Pharmacol Toxicol (Copenh) 1967;25:75–83. doi: 10.1111/j.1600-0773.1967.tb02998.x. [DOI] [PubMed] [Google Scholar]
  5. Freyschuss U. Elicitation of heart rate and blood pressure increase on muscle contraction. J Appl Physiol. 1970 Jun;28(6):758–761. doi: 10.1152/jappl.1970.28.6.758. [DOI] [PubMed] [Google Scholar]
  6. Harrison D. C. Editorial: The pharmacology and therapeutic use of beta-adrenergic receptor blocking drugs in cardiovascular disease. Drugs. 1974;7(1):1–7. doi: 10.2165/00003495-197407010-00001. [DOI] [PubMed] [Google Scholar]
  7. Johnsson G., Regårdh C. G., Sölvell L. Combined pharmacokinetic and pharmacodynammc studies in man of the adrenergic beta1-receptor antagonist metoprolol. Acta Pharmacol Toxicol (Copenh) 1975;36(Suppl 5):31–44. doi: 10.1111/j.1600-0773.1975.tb03320.x. [DOI] [PubMed] [Google Scholar]
  8. Krayenbuehl H. P., Rutishauser W. Hemodynamic consequences and clinical significance of the handgrip test. Eur J Cardiol. 1973 Sep;1(1):5–9. [PubMed] [Google Scholar]
  9. Nyberg G. Blood pressure and heart rate response to isometric exercise and mental arithmetic in normotensive and hypertensive subjects. Clin Sci Mol Med Suppl. 1976 Dec;3:681s–685s. doi: 10.1042/cs051681s. [DOI] [PubMed] [Google Scholar]
  10. Nyberg G. Effect of beta-adrenoreceptor blockers on heart rate and blood pressure in dynamic and isometric exercise. Drugs. 1976;11(Suppl 1):185–195. doi: 10.2165/00003495-197600111-00037. [DOI] [PubMed] [Google Scholar]
  11. Regårdh C. G., Johnsson G., Jordö L., Sölvell L. Comparative bioavailability and effect studies on metoprolol administered as ordinary and slow-release tablets in single and multiple doses. Acta Pharmacol Toxicol (Copenh) 1975;36(Suppl 5):45–58. doi: 10.1111/j.1600-0773.1975.tb03321.x. [DOI] [PubMed] [Google Scholar]
  12. Stenberg J., Wasir H., Amery A., Sannerstedt R., Werkö L. Comparative hemodynamic studies in man of adrenergic bepta-1-receptors agents without (h 93/26 equal to metoprolol) or with (h 87/07) intrinsic sympathicomimetic activity. Acta Pharmacol Toxicol (Copenh) 1975;36(Suppl 5):76–84. doi: 10.1111/j.1600-0773.1975.tb03324.x. [DOI] [PubMed] [Google Scholar]
  13. Whitlock F. A., Price J. Use of beta-adrenergic receptor blocking drugs in psychiatry. Drugs. 1974;8(2):109–124. doi: 10.2165/00003495-197408020-00004. [DOI] [PubMed] [Google Scholar]

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