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. 1979;7(Suppl 2):233S–241S. doi: 10.1111/j.1365-2125.1979.tb04695.x

Inhibitors of the renin-angiotensin system in experiment hypertension, with a note on the measurement of angiotensin I, II and III during infusion of converting-enzyme inhibitor

J J Morton, J Casals-Stenzel, A F Lever, J A Millar, A J G Riegger, M Tree
PMCID: PMC1429317  PMID: 223615

Abstract

1 Prolonged infusion (11 h) of both saralasin and angiotensin-converting enzyme inhibitor (SQ20881) gradually lowered BP in two-kidney hypertensive rats to levels similar to that in normotensive rats infused with dextrose.

2 Saralasin did not lower BP in DOCA-salt-hypertensive rats.

3 These observations support the notion that in chronic renal hypertension, angiotensin II may maintain hypertension by a slowly developing action.

4 Plasma angiotensin II in rats infused with SQ20881 was suppressed relative to renin, but was not eliminated.

5 Chromatography of angiotensin II extracts from dogs infused with converting enzyme inhibitor (SQ14,225) showed that the very high levels of angiotensin I achieved after treatment with SQ14,225 can lead to falsely high estimated angiotensin II levels as a result of angiotensin I cross-reacting with the angiotensin II assay.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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