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. 1979;7(Suppl 2):219S–224S. doi: 10.1111/j.1365-2125.1979.tb04693.x

β-Adrenoceptor-blocking agents and the kidney

Effect of nadolol and propranolol on the renal circulation

Norman K Hollenberg, Douglass F Adams, Doris N McKinstry, Gordon H Williams, Louis J Borucki, Jay M Sullivan
PMCID: PMC1429339  PMID: 37877

Abstract

1 Nadolol was administered intravenously to five hypertensive patients and three healthy volunteers in balance on a 10 mEq sodium intake.

2 Nadolol (0.3-10.0 μg/kg) induced a significant, dose-related increase in renal blood flow, measured with radioxenon, with a maximum increase of 72 ± 4 ml/100g/min (26%) at 3.0 μg/kg.

3 Heart rate and plasma renin activity decreased significantly over the same dose range.

4 The renal vascular response to nadolol contrasts sharply with those found with other β-adrenoceptor-blocking agents.

5 The magnitude of the increase in renal blood flow, its time-course and the parallel fall in plasma renin activity raise the possibility that the renal vasodilatation reflects the reversal of angiotensin's influence on the renal arterial bed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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