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. 1979;7(Suppl 1):151S–155S. doi: 10.1111/j.1365-2125.1979.tb04685.x

Clobazam

Pharmacological and therapeutic profile

G W Hanks
PMCID: PMC1429523  PMID: 35198

Abstract

1 Clobazam is a 1,5-benzodiazepine the pharmacological profile of which differs from that of the 1,4 benzodiazepines in that it displays a wide separation of psychosedative or `tranquillizing' properties from impairment of motor coordination. This is associated with a relative lack of muscle relaxant activity.

2 In man it seems to be an effective anxiolytic agent when given in daily doses of 20-30 mg but produces minimal effects on psychomotor performance at these dose levels.

3 Clobazam has a long elimination half-life of about 18 h; the main metabolite is N-desmethylclobazam. Clobazam seems to share the good safety and tolerability characteristics of the 1,4 benzodiazepines.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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