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. 1979 Sep;8(3):253–260. doi: 10.1111/j.1365-2125.1979.tb01011.x

The pressor actions of noradrenaline, angiotensin II and saralasin in chronic autonomic failure treated with fludrocortisone.

B Davies, R Bannester, P Sever, C Wilcox
PMCID: PMC1429799  PMID: 497092

Abstract

1 Treatment of postural hypotension due to chronic autonomic failure with fludrocortisone increased the pressor sensitivity to intravenous noradrenaline. Fludrocortisone increased the blood pressure in the standing but not the lying position. These effects of fludrocortisone may be the result of increased sensitivity of vascular receptors to noradrenaline. 2 The pressor action of angiotensin II, to which patients were supersensitive, may have involved the stimulation of alpha-adrenoceptors since it was partially antagonised by phentolamine. 3 Saralasin had a marked, paradoxical, pressor effect. This may have been mediated by vascular alpha-adrenoceptors because log dose-response curves of saralasin-induced increases in systolic pressure were shifted to the right in a parallel fashion after phentolamine. 4 Fludrocortisone treatment increased the pressor sensitivity to intravenous saralasin but not to angiotensin-II.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOHR D. F., BRODIE D. C., CHEU D. H. Effect of electrolytes on arterial muscle contraction. Circulation. 1958 Apr;17(4 Pt 2):746–749. doi: 10.1161/01.cir.17.4.746. [DOI] [PubMed] [Google Scholar]
  2. Bannister R., Ardill L., Fentem P. An assessment of various methods of treatment of idiopathic orthostatic hypotension. Q J Med. 1969 Oct;38(152):377–395. [PubMed] [Google Scholar]
  3. Bannister R., Ardill L., Fentem P. Defective autonomic control of blood vessels in idiopathic orthostatic hypotension. Brain. 1967 Dec;90(4):725–746. doi: 10.1093/brain/90.4.725. [DOI] [PubMed] [Google Scholar]
  4. Bannister R., Davies B., Holly E., Rosenthal T., Sever P. Defective cardiovascular reflexes and supersensitivity to sympathomimetic drugs in autonomic failure. Brain. 1979 Mar;102(1):163–176. doi: 10.1093/brain/102.1.163. [DOI] [PubMed] [Google Scholar]
  5. Bannister R., Oppenheimer D. R. Degenerative diseases of the nervous system associated with autonomic failure. Brain. 1972;95(3):457–474. doi: 10.1093/brain/95.3.457. [DOI] [PubMed] [Google Scholar]
  6. Bannister R., Sever P., Gross M. Cardiovascular reflexes and biochemical responses in progressive autonomic failure. Brain. 1977 Jun;100(2):327–344. doi: 10.1093/brain/100.2.327. [DOI] [PubMed] [Google Scholar]
  7. Davies B., Bannister R., Sever P. Pressor amines and monoamine-oxidase inhibitors for treatment of postural hypotension in autonomic failure. Limitations and hazards. Lancet. 1978 Jan 28;1(8057):172–175. doi: 10.1016/s0140-6736(78)90610-4. [DOI] [PubMed] [Google Scholar]
  8. De La Lande I. S., Waterson J. G. Site of action of cocaine on the perfused artery. Nature. 1967 Apr 15;214(5085):313–314. doi: 10.1038/214313a0. [DOI] [PubMed] [Google Scholar]
  9. De la Lande I. S., Hill B. D., Jellett L. B., McNeil J. M. The role of monoamine oxidase in the response of the isolated central artery of the rabbit ear to tyramine. Br J Pharmacol. 1970 Oct;40(2):249–256. doi: 10.1111/j.1476-5381.1970.tb09918.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. GREEN D. M., REYNOLDS T. B., GIRERD R. J. Mechanisms of desoxycorticosterone action. X. Effects on tissue sodium concentration. Am J Physiol. 1955 Apr;181(1):105–113. doi: 10.1152/ajplegacy.1955.181.1.105. [DOI] [PubMed] [Google Scholar]
  11. Gillespie J. S. Uptake of noradrenaline by smooth muscle. Br Med Bull. 1973 May;29(2):136–141. doi: 10.1093/oxfordjournals.bmb.a070983. [DOI] [PubMed] [Google Scholar]
  12. Graham J. G., Oppenheimer D. R. Orthostatic hypotension and nicotine sensitivity in a case of multiple system atrophy. J Neurol Neurosurg Psychiatry. 1969 Feb;32(1):28–34. doi: 10.1136/jnnp.32.1.28. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Hollenberg N. K., Williams G. H., Burger B., Ishikawa I., Adams D. F. Blockade and stimulation of renal, adrenal, and vascular angiotensin II receptors with 1-Sar, 8-Ala angiotensin II in normal man. J Clin Invest. 1976 Jan;57(1):39–46. doi: 10.1172/JCI108266. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Kalsner S. Steroid potentiation of responses to sympathomimetic amines in aortic strips. Br J Pharmacol. 1969 Jul;36(3):582–593. doi: 10.1111/j.1476-5381.1969.tb08013.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Marshall J. M. The effect of uptake by adrenergic nerve terminals on the sensitivity of arterial vessels to topically applied noradrenaline. Br J Pharmacol. 1977 Nov;61(3):429–432. doi: 10.1111/j.1476-5381.1977.tb08436.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. McGrath B. P., Ledingham J. G., Benedict C. R. Plasma catecholamines and the pressor response to Sar1-Ala8-angiotensin II in man. Clin Sci Mol Med. 1977 Oct;53(4):341–348. doi: 10.1042/cs0530341. [DOI] [PubMed] [Google Scholar]
  17. PAGE I. H., McCUBBIN J. W., SCHWARZ H., BUMPUS F. M. Pharmacologic aspects of synthetic angiotonin. Circ Res. 1957 Sep;5(5):552–555. doi: 10.1161/01.res.5.5.552. [DOI] [PubMed] [Google Scholar]
  18. Pals D. T., Masucci F. D., Denning G. S., Jr, Sipos F., Fessler D. C. Role of the pressor action of angiotensin II in experimental hypertension. Circ Res. 1971 Dec;29(6):673–681. doi: 10.1161/01.res.29.6.673. [DOI] [PubMed] [Google Scholar]
  19. Peach M. J., Ober M. Inhibition of angiotensin-induced adrenal catecholamine release by 8-substituted analogs of angiotensin II. J Pharmacol Exp Ther. 1974 Jul;190(1):49–58. [PubMed] [Google Scholar]
  20. Peach M. J. Renin-angiotensin system: biochemistry and mechanisms of action. Physiol Rev. 1977 Apr;57(2):313–370. doi: 10.1152/physrev.1977.57.2.313. [DOI] [PubMed] [Google Scholar]
  21. Regoli D., Park W. K., Rioux F. Pharmacology of angiotensin. Pharmacol Rev. 1974 Jun;26(2):69–123. [PubMed] [Google Scholar]
  22. Richards D. A., Woodings E. P., Prichard B. N. Circulatory and alpha-adrenoceptor blocking effects of phentolamine. Br J Clin Pharmacol. 1978 Jun;5(6):507–513. doi: 10.1111/j.1365-2125.1978.tb01665.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. SHY G. M., DRAGER G. A. A neurological syndrome associated with orthostatic hypotension: a clinical-pathologic study. Arch Neurol. 1960 May;2:511–527. doi: 10.1001/archneur.1960.03840110025004. [DOI] [PubMed] [Google Scholar]
  24. Salt P. J., Iverson L. L. Inhibition of the extraneuronal uptake of catecholamine in the isolated rat heart by cholesterol. Nat New Biol. 1972 Jul 19;238(81):91–92. doi: 10.1038/newbio238091a0. [DOI] [PubMed] [Google Scholar]
  25. Schmid P. G., Eckstein J. W., Abboud F. M. Effect of 9-alpha-fluorohydrocortisone on forearm vascular responses to norepinephrine. Circulation. 1966 Oct;34(4):620–626. doi: 10.1161/01.cir.34.4.620. [DOI] [PubMed] [Google Scholar]
  26. Scroop G. C., Whelan R. F. The effects of alpha-adrenergic receptor blockade and sympathetic denervation of the pressor action of angiotensin in man. Aust J Exp Biol Med Sci. 1968 Oct;46(5):563–572. doi: 10.1038/icb.1968.163. [DOI] [PubMed] [Google Scholar]
  27. Severs W. B., Daniels-Severs A. E. Effects of angiotensin on the central nervous system. Pharmacol Rev. 1973 Sep;25(3):415–449. [PubMed] [Google Scholar]
  28. Starke K., Endo T. Presynaptic alpha-adrenoceptors. Gen Pharmacol. 1976 Oct;7(5):307–312. doi: 10.1016/0306-3623(76)90012-4. [DOI] [PubMed] [Google Scholar]
  29. Streeten D. H., Anderson G. H., Freiberg J. M., Dalakos T. G. Use of an angiotensin II antagonist (saralasin) in the recognition of "angiotensinogenic" hypertension;. N Engl J Med. 1975 Mar 27;292(13):657–662. doi: 10.1056/NEJM197503272921301. [DOI] [PubMed] [Google Scholar]
  30. TAYLOR S. H., SUTHERLAND G. R., MACKENZIE G. J., STAUNTON H. P., DONALD K. W. THE CIRCULATORY EFFECTS OF INTRAVENOUS PHENTOLAMINE IN MAN. Circulation. 1965 May;31:741–754. doi: 10.1161/01.cir.31.5.741. [DOI] [PubMed] [Google Scholar]
  31. TOBIAN L., Jr, BINION J. Artery wall electrolytes in renal and DCA hypertension. J Clin Invest. 1954 Oct;33(10):1407–1414. doi: 10.1172/JCI103018. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. TOBIAN L., REDLEAF P. D. Ionic composition of the aorta in renal and adrenal hypertension. Am J Physiol. 1958 Feb;192(2):325–330. doi: 10.1152/ajplegacy.1958.192.2.325. [DOI] [PubMed] [Google Scholar]
  33. WHITBY L. G., AXELROD J., WEIL-MALHERBE H. The fate of H3-norepinephrine in animals. J Pharmacol Exp Ther. 1961 May;132:193–201. [PubMed] [Google Scholar]
  34. Wilcox C. S., Aminoff M. J. Blood pressure responses to noradrenaline and dopamine infusions in Parkinson's disease and the Shy-Drager syndrome. Br J Clin Pharmacol. 1976 Apr;3(2):207–214. doi: 10.1111/j.1365-2125.1976.tb00594.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

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