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British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1980 Feb;9(2):165–169. doi: 10.1111/j.1365-2125.1980.tb05828.x

Response of pathological ischaemic muscle pain to analgesics.

G Sacchetti, R Lampugnani, C Battistini, V Mandelli
PMCID: PMC1429853  PMID: 7356905

Abstract

1 Twenty-four patients suffering from severe pain due to chronic occlusive arterial disease of the legs were given oral doses of indoprofen (200 mg), ibuprofen (300 mg) and placebo. 2 Differences in pain intensity scored on a five-point scale were taken as measurement of pain relief. 3 This double-blind, cross-over trial showed that indoprofen had significantly greater analgesic effect than placebo and reference drug. 4 From a methodological point of view there are many arguments on favour of pathological ischaemic pain as a test for clinical assessment of analgesics.

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Selected References

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  1. Adler R., Gervasi A., Holzer B., Hemmeler W. Mild analgesics evaluated with the "Submaximum Effort Tourniquet Technique". II. The influence of a tranquilizer on their effect. Psychopharmacologia. 1974;38(4):357–362. doi: 10.1007/BF00429134. [DOI] [PubMed] [Google Scholar]
  2. Adler R., Lomazzi F. Mild analgesics evaluated with the "Submaximum Effort Tourniquet Technique". I. The influence of psychological factors on their effect. Psychopharmacologia. 1974;38(4):351–356. doi: 10.1007/BF00429133. [DOI] [PubMed] [Google Scholar]
  3. BURCH G. E., DEPASQUALE N. P. Bradykinin. Am Heart J. 1963 Jan;65:116–123. doi: 10.1016/0002-8703(63)90221-7. [DOI] [PubMed] [Google Scholar]
  4. Bloomfield S. S., Barden T. P., Mitchell J. Comparative efficacy of ibuprofen and aspirin in episiotomy pain. Clin Pharmacol Ther. 1974 Jun;15(6):565–570. doi: 10.1002/cpt1974156565. [DOI] [PubMed] [Google Scholar]
  5. Buttinoni A., Cuttica A., Franceschini J., Mandelli V., Orsini G., Passerini N., Turba C., Tommasini R. Pharmacological study on a new analgesic-anti-inflammatory drug: alpha-(4-(1-oxo-2-iso-indolinyl)-phenyl)-propionic acid of K 4277. Arzneimittelforschung. 1973 Aug;23(8):1100–1107. [PubMed] [Google Scholar]
  6. Caruso I., Fumagalli M., Marcolongo R., Sacchetti G. Indoprofen for acute gouty arthritis. Arthritis Rheum. 1977 Sep-Oct;20(7):1438–1439. doi: 10.1002/art.1780200729. [DOI] [PubMed] [Google Scholar]
  7. Ceserani R., Ferrari M., Goldaniga G., Moro E., Buttinoni A. Role of protein binding and pharmacokinetics in the lack of correlation between in vitro inhibition of PG-synthetase and in vivo antiinflammatory activity of a homologous series of nonsteroidal antiinflammatory compounds. Life Sci. 1977 Jul 15;21(2):223–229. doi: 10.1016/0024-3205(77)90305-8. [DOI] [PubMed] [Google Scholar]
  8. Crook D., Collins A. J., Bacon P. A., Chan R. Prostaglandin synthetase activity from human rheumatoid synovial microsomes. Effect of 'aspirin-like' drug therapy. Ann Rheum Dis. 1976 Aug;35(4):327–332. doi: 10.1136/ard.35.4.327. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Ferreira S. H., Moncada S., Vane J. R. Prostaglandins and the mechanism of analgesia produced by aspirin-like drugs. Br J Pharmacol. 1973 Sep;49(1):86–97. doi: 10.1111/j.1476-5381.1973.tb08270.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Fjalland B. Influence of various substances on prostaglandin biosynthesis by guinea-pig chopped lung. J Pharm Pharmacol. 1976 Sep;28(9):683–686. doi: 10.1111/j.2042-7158.1976.tb02836.x. [DOI] [PubMed] [Google Scholar]
  11. Fuccella L. M., Conti F., Corvi G., Mandelli V., Randelli M., Stefanelli G. Double-blind study of the analgesic effect of indoprofen (K 4277). Clin Pharmacol Ther. 1975 Mar;17(3):277–283. doi: 10.1002/cpt1975173277. [DOI] [PubMed] [Google Scholar]
  12. Fuccella L. M., Corvi G., Gorini F., Mandelli V., Mascellani G., Nobili F., Pedronetto S., Ragni N., Vandelli I. Application of nonparametric procedure for bioassay data to the evaluation of analgesics in man. J Clin Pharmacol. 1977 Apr;17(4):177–184. doi: 10.1177/009127007701700401. [DOI] [PubMed] [Google Scholar]
  13. Herbaczyńska-Cedro K., Staszewska-Barczak J., Janczewska H. The release of prostaglandin-like substances during reactive and functional hyperemia in the hind leg of the dog. Pol J Pharmacol Pharm. 1974 Jan-Apr;26(1):167–170. [PubMed] [Google Scholar]
  14. Ku E. C., Signor C., Eakins E. Antiinflammatory agents and inhibition of ocular prostaglandin synthetase. Adv Prostaglandin Thromboxane Res. 1976;2:819–823. [PubMed] [Google Scholar]
  15. Lewis J. R. Evaluation of ibuprofen (Motrin). A new antirheumatic agent. JAMA. 1975 Jul 28;233(4):364–365. [PubMed] [Google Scholar]
  16. Marcolongo R., Mandelli V., Magni S. D., Sacchetti G. Indoprofen in knee joint osteoarthritis: a double-blind, crossover clinical trial. J Clin Pharmacol. 1977 Jan;17(1):48–55. doi: 10.1002/j.1552-4604.1977.tb04585.x. [DOI] [PubMed] [Google Scholar]
  17. Minkes M. S., Douglas J. R., Jr, Needleman P. Prostaglandin release by the isolated perfused rabbit heart. Prostaglandins. 1973 Apr;3(4):439–445. doi: 10.1016/0090-6980(73)90151-2. [DOI] [PubMed] [Google Scholar]
  18. Nannini G., Giraldi P. N., Molgora G., Biasoli G., Spinelli F., Logemann W., Dradi E., Zanni G., Buttinoni A., Tommasini R. New analgesic-anti-inflammatory drugs. 1-Oxo-2-substituted isoindoline derivatives. Arzneimittelforschung. 1973 Aug;23(8):1090–1100. doi: 10.1002/chin.197344288. [DOI] [PubMed] [Google Scholar]
  19. Needleman P., Key S. L., Denny S. E., Isakson P. C., Marshall G. R. Mechanism and modification of bradykinin-induced coronary vasodilation. Proc Natl Acad Sci U S A. 1975 Jun;72(6):2060–2063. doi: 10.1073/pnas.72.6.2060. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Sacchetti G., Caputo G., Mandelli V., Fornari R., Magni E. Biliary colic as a model for assessing analgesic activity in man. J Pharmacol Exp Ther. 1977 May;201(2):444–449. [PubMed] [Google Scholar]
  21. Smith G. M., Beecher H. K. Experimental production of pain in man: sensitivity of a new method to 600 mg. of aspirin. Clin Pharmacol Ther. 1969 Mar-Apr;10(2):213–216. doi: 10.1002/cpt1969102213. [DOI] [PubMed] [Google Scholar]
  22. Stygles V. G., Newton J. F., Hook J. B. Inhibition of prostaglandin synthesis by indoprofen. Res Commun Chem Pathol Pharmacol. 1977 Oct;18(2):329–340. [PubMed] [Google Scholar]
  23. Taylor I. Clinical trial comparing pentazocine with pethidine and morphine in severe ischaemic limb pain. Br J Clin Pract. 1971 Jan;25(1):27–30. [PubMed] [Google Scholar]
  24. Ventafridda V., Martino G., Mandelli V., Emanueli A. Indoprofen, a new analgesic and anti-inflammatory drug in cancer pain. Clin Pharmacol Ther. 1975 Mar;17(3):284–289. doi: 10.1002/cpt1975173284. [DOI] [PubMed] [Google Scholar]

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