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. 1980 Feb;9(2):137–143. doi: 10.1111/j.1365-2125.1980.tb05823.x

The pharmacokinetics of methimazole after oral administration of carbimazole and methimazole, in hyperthyroid patients.

G G Skellern, B I Knight, C K Low, W D Alexander, D G McLarty, W J Kalk
PMCID: PMC1429868  PMID: 7356900

Abstract

1 Methimazole plasma concentrations were measured in two groups of hyperthyroid subjects after the oral administration of either carbimazole or methimazole. 2 With the HPLC method it was also possible to measure the concentration of a methimazole metabolite, 3-methyl-2-thiohydantoin in one patient. 3 Large interindividual differences were observed, especially within the carbimazole group. 4 Incomplete absorption of carbimazole could explain particular high apparent volumes of distribution and apparent clearances.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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