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. 1979 Dec;8(6):523–528. doi: 10.1111/j.1365-2125.1979.tb01039.x

Reduction of circulating 25-hydroxyvitamin D by antipyrine.

P F Wilmana, M J Brodie, J C Mucklow, H S Fraser, E L Toverud, D S Davies, C T Dollery, C J Hillyard, I Macintyre, B K Park
PMCID: PMC1429906  PMID: 533574

Abstract

1 Twenty-four Asian vegetarians had significantly lower 25-hydroxyvitamin D (25-OHD) levels and longer antipyrine half-lives than twenty white non-vegetarians (P less than 0.001). 2 Treatment with oral antipyrine over 4 or 5 weeks in seven vegetarian Asians and five racially different non-vegetarians increased drug oxidation significantly in both groups as measured by a fall in antipyrine half-lives and a rise in serum gamma-glutamyltranspeptidase levels and urinary 6 beta-hydroxycortisol/17-hydroxycorticosteroid ratios. 3 Antipyrine treatment produced a fall in circulating 25-hydroxyvitamin D of around 60% in all subjects in whom pretreatment levels could be measured, independent of race and diet. 4. In the Caucasian non-vegetarian group 1,25 dihidroxyvitamin D levels, the most active metabolite of vitamin D, were also measured and remained unaltered despite a substantial fall in 25-hydroxy substrate. 5 The acute fall in 25-hydroxyvitamin D concentration with a maintained level of 1,25 dihidroxyvitamin D may represent the early changes of drug-induced osteomalacia.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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