Abstract
1. The effect of ampicillin, cloxacillin, flucloxacillin and sulphafurazole on bilirubin on bilirubin binding by pooled human umbilical cord serum and bovine serum albumin was studied in vitro using Sephadex gel filtration. 2. Sulphafurazole displaced bilirubin from binding; both cloxacillins displaced bilirubin from pooled cord serum but not bovine serum albumin. 4. No displacement of bilirubin by the cloxacillins from pooled cord serum could be detected at therapeutic plasma concentrations of these drugs. 5. Scatchard analysis of the interactions showed that displacement of bilirubin by these drugs occurred principally at the primary, high affinity, low capacity binding site.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ANDERSEN D. H., BLANC W. A., CROZIER D. N., SILVERMAN W. A. A difference in mortality rate and incidence of kernicterus among premature infants allotted to two prophylactic antibacterial regimens. Pediatrics. 1956 Oct;18(4):614–625. [PubMed] [Google Scholar]
- Anton A. H. Drug-protein binding. IV. Modulation of binding. Increasing activity of sulfonamides with displacing agents: a review. Ann N Y Acad Sci. 1973 Nov 26;226:273–292. doi: 10.1111/j.1749-6632.1973.tb20490.x. [DOI] [PubMed] [Google Scholar]
- Bratlid D. The effect of antimicrobial agents on bilirubin binding by human erythrocytes. Scand J Clin Lab Invest. 1972 Nov;30(3):331–337. doi: 10.3109/00365517209084298. [DOI] [PubMed] [Google Scholar]
- Cohen M. D., Raeburn J. A., Devine J., Kirkwood J., Elliott B., Cockburn F., Forfar J. O. Pharmacology of some oral penicillins in the newborn infant. Arch Dis Child. 1975 Mar;50(3):230–234. doi: 10.1136/adc.50.3.230. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Coutinho C. B., Lucek R. W., Cheripko J. A., Kuntzman R. A new approach to the determination of protein-bound bilirubin displacement and its applications. Ann N Y Acad Sci. 1973 Nov 26;226:238–246. doi: 10.1111/j.1749-6632.1973.tb20485.x. [DOI] [PubMed] [Google Scholar]
- Hanefeld F., Ballowitz L. Letter: Flucloxacillin and bilirubin binding. Lancet. 1976 Feb 21;1(7956):433–434. doi: 10.1016/s0140-6736(76)90283-x. [DOI] [PubMed] [Google Scholar]
- Kaufmann N. A., Kapitulnik J., Blondheim S. H. The adsorption of bilirubin by Sephadex and its relationship to the criteria for exchange transfusion. Pediatrics. 1969 Oct;44(4):543–548. [PubMed] [Google Scholar]
- Krasner J., Giacoia G. P., Yaffe S. J. Drug-protein binding in the newborn infant. Ann N Y Acad Sci. 1973 Nov 26;226:101–114. doi: 10.1111/j.1749-6632.1973.tb20473.x. [DOI] [PubMed] [Google Scholar]
- Kunin C. M. Clinical significance of protein binding of the penicillins. Ann N Y Acad Sci. 1967 Sep 27;145(2):282–290. doi: 10.1111/j.1749-6632.1967.tb50225.x. [DOI] [PubMed] [Google Scholar]
- Meuwissen J. A., Heirwegh K. P. Transfer of adsorbed bilirubin to specific binding proteins. Biochem J. 1970 Dec;120(4):19P–19P. doi: 10.1042/bj1200019p. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ODELL G. B. The dissociation of bilirubin from albumin and its clinical implications. J Pediatr. 1959 Sep;55:268–279. doi: 10.1016/s0022-3476(59)80223-7. [DOI] [PubMed] [Google Scholar]
- Satge P., Colin J., Voyer M., Crumiere C., Charlas J. Place des dosages de la bilirubine non liée et de l'albumine sérique dans la surveillance des icteres du prémature. Arch Fr Pediatr. 1974 Feb-Mar;31(2):201–213. [PubMed] [Google Scholar]
- Schiff D., Chan G., Stern L. Sephadex G-25 quantitative estimation of free bilirubin potential in jaundiced newborn infants sera: a guide to the prevention of kernicterus. J Lab Clin Med. 1972 Sep;80(3):455–462. [PubMed] [Google Scholar]
- Tan J. S., Trott A., Phair J. P., Watanakunakorn C. A method for measurement of antibiotics in human interstitial fluid. J Infect Dis. 1972 Nov;126(5):492–497. doi: 10.1093/infdis/126.5.492. [DOI] [PubMed] [Google Scholar]