Abstract
1 The effects of methyldopa withdrawal on liver function and drug metabolism were investigated in ten elderly females suffering from the drug-induced orthostatic reaction and resistant hypertension. 2 There was a significant increase in serum albumin level, antipyrine metabolism and urinary excretion of D-glucaric acid 6 months after the methyldopa withdrawal. 3 The results suggest that patients treated with methyldopa might show a reduced metabolizing ability in spite of normal liver function tests.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barrett P. V. Effects of caloric and noncaloric materials in fasting hyperbilirubinemia. Gastroenterology. 1975 Feb;68(2):361–369. [PubMed] [Google Scholar]
- Bottazzo G. F., Florin-Christensen A., Fairfax A., Swana G., Doniach D., Groeschel-Stewart U. Classification of smooth muscle autoantibodies detected by immunofluorescence. J Clin Pathol. 1976 May;29(5):403–410. doi: 10.1136/jcp.29.5.403. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dybing E., Nelson S. D., Mitchell J. R., Sasame H. A., Gillette J. R. Oxidation of alpha-methyldopa and other catechols by cytochrome P-450-generated superoxide anion: possible mechanism of methyldopa hepatitis. Mol Pharmacol. 1976 Nov;12(6):911–920. [PubMed] [Google Scholar]
- MARSH C. A., CARR A. J. CHANGES IN ENZYME ACTIVITY, RELATED TO D-GLUCARIC ACID SYNTHESIS, WITH AGE, PREGNANCY AND MALIGNANCY. Clin Sci. 1965 Apr;28:209–217. [PubMed] [Google Scholar]
- O'Malley K., Crooks J., Duke E., Stevenson I. H. Effect of age and sex on human drug metabolism. Br Med J. 1971 Sep 11;3(5775):607–609. doi: 10.1136/bmj.3.5775.607. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Prescott L. F., Adjepon-Yamoah K. K., Roberts E. Rapid gas-liquid chromatographic estimation of antipyrine in plasma. J Pharm Pharmacol. 1973 Mar;25(3):205–207. doi: 10.1111/j.2042-7158.1973.tb10625.x. [DOI] [PubMed] [Google Scholar]
- Sotaniemi E. A., Ahlqvist J., Pelkonen R. O., Pirttiaho H., Luoma P. V. Histological changes in the liver and indices of drug metabolism in alcoholics. Eur J Clin Pharmacol. 1977 Apr 20;11(4):295–303. doi: 10.1007/BF00607680. [DOI] [PubMed] [Google Scholar]
- Sotaniemi E. A., Hokkanen O. T., Ahokas J. T., Pelkonen R. O., Ahlqvist J. Hepatic injury and drug metabolism in patients with alpha-methyldopa-induced liver damage. Eur J Clin Pharmacol. 1977 Dec 28;12(6):429–435. doi: 10.1007/BF00561062. [DOI] [PubMed] [Google Scholar]
- Sotaniemi E. A., Medzihradsky F., Eliasson G. Glucaric acid as an indicator of use of enzyme-inducing drugs. Clin Pharmacol Ther. 1974 Apr;15(4):417–423. doi: 10.1002/cpt1974154417. [DOI] [PubMed] [Google Scholar]
- Toghill P. J., Smith P. G., Benton P., Brown R. C., Matthews H. L. Methyldopa liver damage. Br Med J. 1974 Aug 31;3(5930):545–548. doi: 10.1136/bmj.3.5930.545. [DOI] [PMC free article] [PubMed] [Google Scholar]