Skip to main content
PMC home page
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1980 Sep;10(3):237–244. doi: 10.1111/j.1365-2125.1980.tb01750.x

Disopyramide and lignocaine. A comparison of cardiac effects using echocardiography.

M A Martin, N D Bax, G T Tucker, J W Ward
PMCID: PMC1430075  PMID: 7437240

Abstract

1 The cardiac effects of disopyramide (D) and lignocaine (L) were measured and compared in normal volunteers (D n=4; L n=3) following the establishment of a series of three steady-state drug plasma concentrations spanning the therapeutic range (1.5-5 micrograms base ml-1). 2 During control and steady-state periods multiple measurements were made of heart rate, blood pressure, drug concentrations and echocardiographic measurement of cardiac dimensions and estimated left ventricular function. 3 No change in heart size or estimated function occurred with L except for a small increase in estimated cardiac output (+0.5 1 min-1) secondary to a small rise in heart rate (maximum +7 beats min-1). Blood pressure rose slightly (maximum +11 mmHg). 4 D caused an increase in heart size, marked at end systole (+0.63 cm), and a decrease in echo indices of ventricular function (25-33%). These changes were related to plasma drug concentration but were not reflected in cardiac output estimation since heart rate rose (+15 beats min-1). Blood pressure also rose (+10 mmHg). 5 Significant differences were shown between D and L at similar plasma drug concentrations. The negative inotropic effect of D may be greater than previously suggested and clinically important.

Full text

PDF
240

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Binnion P. F., Murtagh G., Pollock A. M., Fletcher E. Relation between plasma lignocaine levels and induced haemodynamic changes. Br Med J. 1969 Aug 16;3(5667):390–392. doi: 10.1136/bmj.3.5667.390. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Chamberlain D. A., Turner P., Sneddon J. M. Effects of atropine on heart-rate in healthy man. Lancet. 1967 Jul 1;2(7505):12–15. doi: 10.1016/s0140-6736(67)90057-8. [DOI] [PubMed] [Google Scholar]
  3. Danilo P., Jr, Rosen M. R. Cardiac effects of disopyramide. Am Heart J. 1976 Oct;92(4):532–536. doi: 10.1016/s0002-8703(76)80054-3. [DOI] [PubMed] [Google Scholar]
  4. Davies G. J., Marrott P. K., Muir J. R. Haemodynamic and electrocardiographic effects of intravenous disopyramide (rythmodan) following acute myocardial infarction. Br J Clin Pharmacol. 1979 Feb;7(2):183–187. doi: 10.1111/j.1365-2125.1979.tb00919.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. DeMaria A. N., Neumann A., Schubart P. J., Lee G., Mason D. T. Systematic correlation of cardiac chamber size and ventricular performance determined with echocardiography and alterations in heart rate in normal persons. Am J Cardiol. 1979 Jan;43(1):1–9. doi: 10.1016/0002-9149(79)90036-5. [DOI] [PubMed] [Google Scholar]
  6. Delgado C. E., Gortuin N. J., Ross R. S. Acute effects of low doses of alcohol on left ventricular function by echocardiography. Circulation. 1975 Mar;51(3):535–540. doi: 10.1161/01.cir.51.3.535. [DOI] [PubMed] [Google Scholar]
  7. Fortuin N. J., Pawsey C. G. The evaluation of left ventricular function by echocardiography. Am J Med. 1977 Jul;63(1):1–9. doi: 10.1016/0002-9343(77)90112-7. [DOI] [PubMed] [Google Scholar]
  8. Gianelly R., von der Groeben J. O., Spivack A. P., Harrison D. C. Effect of lidocaine on ventricular arrhythmias in patients with coronary heart disease. N Engl J Med. 1967 Dec 7;277(23):1215–1219. doi: 10.1056/NEJM196712072772301. [DOI] [PubMed] [Google Scholar]
  9. Gibson D. G. Use of M-mode echocardiography in clinical pharmacology. Br J Clin Pharmacol. 1979 May;7(5):443–449. doi: 10.1111/j.1365-2125.1979.tb00984.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Grossman J. I., Cooper J. A., Frieden J. Cardiovascular effects of infusion of lidocaine on patients with heart disease. Am J Cardiol. 1969 Aug;24(2):191–197. doi: 10.1016/0002-9149(69)90403-2. [DOI] [PubMed] [Google Scholar]
  11. Gutgesell H. P., Paquet M., Duff D. F., McNamara D. G. Evaluation of left ventricular size and function by echocardiography. Results in normal children. Circulation. 1977 Sep;56(3):457–462. doi: 10.1161/01.cir.56.3.457. [DOI] [PubMed] [Google Scholar]
  12. Hayler A. M., Flanagan R. J. Simple gas-liquid chromatographic method for the measurement of disopyramide in blood-plasma or serum and in urine. J Chromatogr. 1978 Jun 11;153(2):461–471. doi: 10.1016/s0021-9673(00)95506-7. [DOI] [PubMed] [Google Scholar]
  13. Heel R. C., Brogden R. N., Speight T. M., Avery G. S. Disopyramide: a review of its pharmacological properties and therapeutic use in treating cardiac arrhythmias. Drugs. 1978 May;15(5):331–368. [PubMed] [Google Scholar]
  14. Hirshleifer J., Crawford M., O'Rourke R. A., Karliner J. S. Influence of acute alterations in heart rate and systemic arterial pressure on echocardiographic measures of left ventricular perfornmance in normal human subjects. Circulation. 1975 Nov;52(5):835–841. doi: 10.1161/01.cir.52.5.835. [DOI] [PubMed] [Google Scholar]
  15. Hulting J., Rosenhamer G. Kinetics of hemodynamic and electrocardiographic changes following intravenous disopyramide. Acta Med Scand. 1979;205(5):417–423. doi: 10.1111/j.0954-6820.1979.tb06075.x. [DOI] [PubMed] [Google Scholar]
  16. Irgens T. R., Henderson W. M., Shelver W. H. GLC analysis of lidocaine in blood using an alkaline flame-ionization detector. J Pharm Sci. 1976 Apr;65(4):608–610. doi: 10.1002/jps.2600650435. [DOI] [PubMed] [Google Scholar]
  17. Jensen G., Sigurd B., Uhrenholt A. Haemodynamic effects of intravenous disopyramide in heart failure. Eur J Clin Pharmacol. 1975 Apr 4;8(3-4):167–173. doi: 10.1007/BF00567110. [DOI] [PubMed] [Google Scholar]
  18. KAO F. F., JALAR U. H. The central action of lignocaine and its effect on cardiac output. Br J Pharmacol Chemother. 1959 Dec;14:522–526. doi: 10.1111/j.1476-5381.1959.tb00959.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Klein S. W., Sutherland R. I., Morch J. E. Hemodynamic effects of intravenous lidocaine in man. Can Med Assoc J. 1968 Sep 14;99(10):472–475. [PMC free article] [PubMed] [Google Scholar]
  20. Martin M. A., Fieller N. R. Echocardiography in cardiovascular drug assessment. Br Heart J. 1979 May;41(5):536–543. doi: 10.1136/hrt.41.5.536. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Quinones M. A., Gaasch W. H., Cole J. S., Alexander J. K. Echocardiographic determination of left ventricular stress-velocity relations. Circulation. 1975 Apr;51(4):689–700. doi: 10.1161/01.cir.51.4.689. [DOI] [PubMed] [Google Scholar]
  22. Wagner J. G. A safe method for rapidly achieving plasma concentration plateaus. Clin Pharmacol Ther. 1974 Oct;16(4):691–700. doi: 10.1002/cpt1974164691. [DOI] [PubMed] [Google Scholar]
  23. Wiklund L. Human hepatic blood flow and its relation to systemic circulation during intravenous infusion of lidocaine. Acta Anaesthesiol Scand. 1977;21(2):148–160. doi: 10.1111/j.1399-6576.1977.tb01204.x. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES