Abstract
The incidence of colorectal cancer was studied by the actuarial method in 959 patients with idiopathic proctocolitis seen from 1942 to 1981. Forty five per cent had rectal, 23% left-sided, and 32% total involvement of the colon. Six cancers were found: one in the rectal, one in the left-sided, and four in the total form of the disease. The risk of cancer per patient year in total colitis was zero per 2151 patient years in the first decade, 1/462 in the second decade, 1/315 in the third decade, and 1/75 in the fourth decade. The cumulative risk of developing cancer was zero at 10 years of duration of the disease, approximately 5% at 20 years, 15% at 30 years, and 20% at 35 years. This increase in risk of cancer is less than reported in some other series. Geographical differences in the incidence of cancer in proctocolitis could influence the risk and therefore also the long-term management of patients with proctocolitis in different geographical areas.
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- BERKSON J., GAGE R. P. Calculation of survival rates for cancer. Proc Staff Meet Mayo Clin. 1950 May 24;25(11):270–286. [PubMed] [Google Scholar]
- Baker W. N., Glass R. E., Ritchie J. K., Aylett S. O. Cancer of the rectum following colectomy and ileorectal anastomosis for ulcerative colitis. Br J Surg. 1978 Dec;65(12):862–868. doi: 10.1002/bjs.1800651211. [DOI] [PubMed] [Google Scholar]
- Bitter J., Hulec J. Ulcerózní kolitida v Severoceském kraji. Cesk Gastroenterol Vyz. 1980 May;34(3):137–144. [PubMed] [Google Scholar]
- De Dombal F. T., Watts J. M., Watkinson G., Goligher J. C. Local complications of ulcerative colitis: stricture, pseudopolyposis, and carcinoma of colon and rectum. Br Med J. 1966 Jun 11;1(5501):1442–1447. doi: 10.1136/bmj.1.5501.1442. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Devroede G. J., Taylor W. F., Sauer W. G., Jackman R. J., Stickler G. B. Cancer risk and life expectancy of children with ulcerative colitis. N Engl J Med. 1971 Jul 1;285(1):17–21. doi: 10.1056/NEJM197107012850103. [DOI] [PubMed] [Google Scholar]
- Devroede G., Taylor W. F., Greenstein A. J., Janowitz H. D. Comment calculer l'histoire naturelle d'une maladie? Gastroenterol Clin Biol. 1979 Mar;3(3):259–265. [PubMed] [Google Scholar]
- Devroede G., Taylor W. F. On calculating cancer risk and survival of ulcerative colitis patients with the life table method. Gastroenterology. 1976 Sep;71(3):505–509. [PubMed] [Google Scholar]
- EDWARDS F. C., TRUELOVE S. C. THE COURSE AND PROGNOSIS OF ULCERATIVE COLITIS. III. COMPLICATIONS. Gut. 1964 Feb;5:1–22. doi: 10.1136/gut.5.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Greenstein A. J., Sachar D. B., Smith H., Pucillo A., Papatestas A. E., Kreel I., Geller S. A., Janowitz H. D., Aufses A. H., Jr Cancer in universal and left-sided ulcerative colitis: factors determining risk. Gastroenterology. 1979 Aug;77(2):290–294. [PubMed] [Google Scholar]
- Grundfest S. F., Fazio V., Weiss R. A., Jagelman D., Lavery I., Weakley F. L., Turnbull R. B., Jr The risk of cancer following colectomy and ileorectal anastomosis for extensive mucosal ulcerative colitis. Ann Surg. 1981 Jan;193(1):9–14. doi: 10.1097/00000658-198101000-00002. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lennard-Jones J. E., Morson B. C., Ritchie J. K., Shove D. C., Williams C. B. Cancer in colitis: assessment of the individual risk by clinical and histological criteria. Gastroenterology. 1977 Dec;73(6):1280–1289. [PubMed] [Google Scholar]
- Prior P., Gyde S., Cooke W. T., Waterhouse J. A., Allan R. N. Mortality in Crohn's disease. Gastroenterology. 1981 Feb;80(2):307–312. [PubMed] [Google Scholar]