Abstract
Eighty two patients with an endoscopically healed gastric ulcer, were treated for two years with either Caved-S tablets, two twice daily or cimetidine 400 mg at night. During the first year, 12% (four out of 34) of the Caved-S group and 10% (four out of 41) of the cimetidine group had an ulcer recurrence. By the end of the second year, the recurrence rate was 29% (nine out of 31) in the Caved-S group, and 25% (eight out of 32) for the cimetidine group. Ulcer relapse occurred frequently in patients with either a dyspeptic history of over six months (p less than 0.05), or a past history of a gastric ulcer (p less than 0.001). Ulcers recurred rapidly after maintenance therapy; Caved-S two out of 22; cimetidine seven out of 23, within four months (NS). This study shows that long term maintenance therapy is safe and reasonably effective. The high recurrence rate after stopping treatment suggests that therapy in high risk or elderly patients should be for life.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Alstead E. M., Ryan F. P., Holdsworth C. D., Ashton M. G., Moore M. Ranitidine in the prevention of gastric and duodenal ulcer relapse. Gut. 1983 May;24(5):418–420. doi: 10.1136/gut.24.5.418. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Baron J. H., Alexander-Williams J., Bennett J. R. Cimetidine and duodenal ulcer. Br Med J. 1979 Jan 20;1(6157):169–173. doi: 10.1136/bmj.1.6157.169. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Barr G. D., Kang J. Y., Canalese J., Piper D. W. A two-year prospective controlled study of maintenance cimetidine and gastric ulcer. Gastroenterology. 1983 Jul;85(1):100–104. [PubMed] [Google Scholar]
- Dronfield M. W., Batchelor A. J., Larkworthy W., Langman M. J. Controlled trial of maintenance cimetidine treatment in healed duodenal ulcer: short and long-term effects. Gut. 1979 Jun;20(6):526–530. doi: 10.1136/gut.20.6.526. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hentschel E., Schütze K., Weiss W., Rüdiger E., Judmair G., Reichel W., Kerstan E., Horton J. Effect of cimetidine treatment in the prevention of gastric ulcer relapse: a one year double blind multicentre study. Gut. 1983 Sep;24(9):853–856. doi: 10.1136/gut.24.9.853. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jensen K. B., Møllmann K. M., Rahbek I., Madsen J. R., Rune S. J., Wulff H. R. Prophylactic effect of cimetidine in gastric ulcer patients. Scand J Gastroenterol. 1979;14(2):175–176. doi: 10.3109/00365527909179865. [DOI] [PubMed] [Google Scholar]
- Machell R. J., Ciclitira P. J., Farthing M. J., Dick A. P., Hunter J. O. Cimetidine in the prevention of gastric ulcer relapse. Postgrad Med J. 1979 Jun;55(644):393–395. doi: 10.1136/pgmj.55.644.393. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morgan A. G., McAdam W. A., Pacsoo C., Darnborough A. Comparison between cimetidine and Caved-S in the treatment of gastric ulceration, and subsequent maintenance therapy. Gut. 1982 Jun;23(6):545–551. doi: 10.1136/gut.23.6.545. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Peto R., Pike M. C., Armitage P., Breslow N. E., Cox D. R., Howard S. V., Mantel N., McPherson K., Peto J., Smith P. G. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. Br J Cancer. 1977 Jan;35(1):1–39. doi: 10.1038/bjc.1977.1. [DOI] [PMC free article] [PubMed] [Google Scholar]