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. 1987 Jun;28(6):668–674. doi: 10.1136/gut.28.6.668

Hepatic sarcomas in adults: a review of 25 cases.

A Forbes, B Portmann, P Johnson, R Williams
PMCID: PMC1433048  PMID: 3623214

Abstract

Twenty-five patients with an apparently primary sarcoma of the liver are reviewed. Presenting complaints were non-specific, but hepatomegaly and abnormal liver function tests were usual. Use of the contraceptive pill (four of 11 women) was identified as a possible risk factor; one patient had previously been exposed to vinyl chloride monomer. Detailed investigation showed that the primary tumour was extrahepatic in nine of the 25 patients. Distinguishing features of the 15 patients with confirmed primary hepatic sarcoma included a lower incidence of multiple hepatic lesions and a shorter time from first symptoms to diagnosis, but the most valuable discriminator was histology. Angiosarcomas and undifferentiated tumours were all of hepatic origin, epithelioid haemangioendotheliomas (EHAE) occurred as primary and secondary lesions and all other differentiated tumours arose outside the liver. The retroperitoneum was the most common site of an occult primary tumour and its careful examination therefore crucial: computed tomography scanning was found least fallible in this respect in the present series. Where resection (or transplantation), the best treatment, was not possible, results of therapy were disappointing, prognosis being considerably worse for patients with primary hepatic tumours. Patients with EHAE had a better overall prognosis regardless of primary site.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chen K. T. Hepatic leiomyosarcoma. J Surg Oncol. 1983 Dec;24(4):325–328. doi: 10.1002/jso.2930240417. [DOI] [PubMed] [Google Scholar]
  2. Das Gupta T. K., Patel M. K., Chaudhuri P. K., Briele H. A. The role of chemotherapy as an adjuvant to surgery in the initial treatment of primary soft tissue sarcomas in adults. J Surg Oncol. 1982 Mar;19(3):139–144. doi: 10.1002/jso.2930190306. [DOI] [PubMed] [Google Scholar]
  3. Dean P. J., Haggitt R. C., O'Hara C. J. Malignant epithelioid hemangioendothelioma of the liver in young women. Relationship to oral contraceptive use. Am J Surg Pathol. 1985 Oct;9(10):695–704. doi: 10.1097/00000478-198510000-00001. [DOI] [PubMed] [Google Scholar]
  4. Ishak K. G., Sesterhenn I. A., Goodman Z. D., Rabin L., Stromeyer F. W. Epithelioid hemangioendothelioma of the liver: a clinicopathologic and follow-up study of 32 cases. Hum Pathol. 1984 Sep;15(9):839–852. doi: 10.1016/s0046-8177(84)80145-8. [DOI] [PubMed] [Google Scholar]
  5. Lee Y. T. Leiomyosarcoma of the gastro-intestinal tract: general pattern of metastasis and recurrence. Cancer Treat Rev. 1983 Jun;10(2):91–101. doi: 10.1016/0305-7372(83)90007-5. [DOI] [PubMed] [Google Scholar]
  6. Macmahon H. E., Murphy A. S., Bates M. I. Endothelial-Cell Sarcoma of Liver Following Thorotrast Injections. Am J Pathol. 1947 Jul;23(4):585–611. [PMC free article] [PubMed] [Google Scholar]
  7. Mark L., Delmore F., Creech J. L., Jr, Ogden LL I. I., Fadell E. H., Songster C. L., Clanton J., Johnson M. N., Christopherson W. M. Clinical and morphologic features of hepatic angiosarcoma in vinyl chloride workers. Cancer. 1976 Jan;37(1):149–163. doi: 10.1002/1097-0142(197601)37:1<149::aid-cncr2820370122>3.0.co;2-7. [DOI] [PubMed] [Google Scholar]
  8. Miettinen M., Lehto V. P., Virtanen I. Antibodies to intermediate filament proteins in the diagnosis and classification of human tumors. Ultrastruct Pathol. 1984;7(2-3):83–107. doi: 10.3109/01913128409141467. [DOI] [PubMed] [Google Scholar]
  9. Neuberger J., Forman D., Doll R., Williams R. Oral contraceptives and hepatocellular carcinoma. Br Med J (Clin Res Ed) 1986 May 24;292(6532):1355–1357. doi: 10.1136/bmj.292.6532.1355. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Regelson W., Kim U., Ospina J., Holland J. F. Hemangioendothelial sarcoma of liver from chronic arsenic intoxication by Fowler's solution. Cancer. 1968 Mar;21(3):514–522. doi: 10.1002/1097-0142(196803)21:3<514::aid-cncr2820210323>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  11. Stocker J. T., Ishak K. G. Undifferentiated (embryonal) sarcoma of the liver: report of 31 cases. Cancer. 1978 Jul;42(1):336–348. doi: 10.1002/1097-0142(197807)42:1<336::aid-cncr2820420151>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  12. Stuart-Harris R. C., Harper P. G., Parsons C. A., Kaye S. B., Mooney C. A., Gowing N. F., Wiltshaw E. High-dose alkylation therapy using ifosfamide infusion with mesna in the treatment of adult advanced soft-tissue sarcoma. Cancer Chemother Pharmacol. 1983;11(2):69–72. doi: 10.1007/BF00254247. [DOI] [PubMed] [Google Scholar]
  13. Suit H. D., Mankin H. J., Wood W. C., Proppe K. H. Preoperative, intraoperative, and postoperative radiation in the treatment of primary soft tissue sarcoma. Cancer. 1985 Jun 1;55(11):2659–2667. doi: 10.1002/1097-0142(19850601)55:11<2659::aid-cncr2820551122>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
  14. Sussman E. B., Nydick I., Gray G. F. Hemangioendothelial sarcoma of the liver and hemochromatosis. Arch Pathol. 1974 Jan;97(1):39–42. [PubMed] [Google Scholar]

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