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. 1988 Mar;29(3):279–283. doi: 10.1136/gut.29.3.279

Effect of treatment on Campylobacter pylori in peptic disease: a randomised prospective trial.

H Humphreys 1, S Bourke 1, C Dooley 1, D McKenna 1, B Power 1, C T Keane 1, E C Sweeney 1, C O'Moráin 1
PMCID: PMC1433591  PMID: 3356357

Abstract

This study investigated the effect of colloidal bismuth subcitrate and cimetidine on Campylobacter pylori in peptic disease. In 74% of 135 patients with peptic disease diagnosed at endoscopy C pylori was detected before treatment. Compared with cimetidine, colloidal bismuth subcitrate significantly decreased the incidence of C pylori after six weeks of treatment (p less than 0.001). In the colloidal bismuth subcitrate group, subsequent healing of the lesion was correlated with the clearance of C pylori, unlike in the cimetidine group. C pylori was strongly associated with the presence of histological gastritis, which was decreased by colloidal bismuth subcitrate (p less than 0.001).

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Selected References

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