Skip to main content
PMC home page
Gut logoLink to Gut
. 1988 Jul;29(7):916–925. doi: 10.1136/gut.29.7.916

Immunoglobulin containing cells in terminal ileum and colorectum of patients with arthritis related gut inflammation.

C Cuvelier 1, H Mielants 1, M De Vos 1, E Veys 1, H Roels 1
PMCID: PMC1433752  PMID: 3396965

Abstract

In 40 distal ileal and 40 colonic biopsies of arthritic patients mostly without gastrointestinal symptoms, but with histological evidence of acute or chronic inflammation of the gut, the number of immunoglobulin (Ig) containing plasma cells was studied morphometrically using a peroxidase antiperoxidase technique. Compared with controls, the ileal mucosal biopsies showed an increase of IgA and IgG in acute ileitis. In chronic ileitis there was an increase of IgA, IgG, and IgM similar to Crohn's disease. In colonic biopsies there was a significant increase of all immunoglobulin classes in acute inflammation. In chronic inflamed mucosa there was also an increase of all three Ig classes. The Ig distribution, however, was significantly different in acute and chronic colitis. These findings give immunohistochemical evidence of the existence of two different types of inflammation related to reactive arthritis or the peripheral joint involvement of ankylosing spondylitis. The Ig pattern in acute colitis is similar to that found in infectious colitis, suggesting an enterobacterial origin of the arthritis in this group of patients although bacteriological and serological investigations were negative. In the chronic type of arthritis related ileocolitis, the pattern of Ig containing cells is similar to that found in Crohn's disease but different from infectious and ulcerative colitis, which makes the hypothesis that a great number of these arthritis patients suffer from asymptomatic or subclinical Crohn's disease acceptable.

Full text

PDF
920

Images in this article

918Fig. 1
on p.918
922Fig. 4
on p.922
923Fig. 5
on p.923

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baklien K., Brandtzaeg P. Comparative mapping of the local distribution of immunoglobulin-containing cells in ulcerative colitis and Crohn's disease of the colon. Clin Exp Immunol. 1975 Nov;22(2):197–209. [PMC free article] [PubMed] [Google Scholar]
  2. Baklien K., Brandtzaeg P. Immunohistochemical characterization of local immunoglobulin formation in Crohn's disease of the ileum. Scand J Gastroenterol. 1976;11(5):447–457. [PubMed] [Google Scholar]
  3. Bosman F. T., Lindeman J., Kuiper G., van der Wal A., Kreunig J. The influence of fixation on immunoperoxidase staining of plasmacells in paraffin sections of intestinal biopsy specimens. Histochemistry. 1977 Jul 18;53(1):57–62. doi: 10.1007/BF00511210. [DOI] [PubMed] [Google Scholar]
  4. Brandtzaeg P., Baklien K., Fausa O., Hoel P. S. Immunohistochemical characterization of local immunoglobulin formation in ulcerative colitis. Gastroenterology. 1974 Jun;66(6):1123–1136. [PubMed] [Google Scholar]
  5. Brewerton D. A., Hart F. D., Nicholls A., Caffrey M., James D. C., Sturrock R. D. Ankylosing spondylitis and HL-A 27. Lancet. 1973 Apr 28;1(7809):904–907. doi: 10.1016/s0140-6736(73)91360-3. [DOI] [PubMed] [Google Scholar]
  6. Cuvelier C., Barbatis C., Mielants H., De Vos M., Roels H., Veys E. Histopathology of intestinal inflammation related to reactive arthritis. Gut. 1987 Apr;28(4):394–401. doi: 10.1136/gut.28.4.394. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Meijer C. J., Bosman F. T., Lindeman J. Evidence for predominant involvement of the B-cell system in the inflammatory process in Crohn's disease. Scand J Gastroenterol. 1979;14(1):21–32. doi: 10.3109/00365527909179842. [DOI] [PubMed] [Google Scholar]
  8. Meuwissen S. G., Feltkamp-Vroom T. M., De La Rivière A. B., Von Dem Borne A. E., Tytgat G. N. Analysis of the lympho-plasmacytic infiltrate in Crohn's disease with special reference to identification of lymphocyte-subpopulations. Gut. 1976 Oct;17(10):770–780. doi: 10.1136/gut.17.10.770. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Mielants H., Veys E. M., Joos R., Cuvelier C., De Vos M. Repeat ileocolonoscopy in reactive arthritis. J Rheumatol. 1987 Jun;14(3):456–458. [PubMed] [Google Scholar]
  10. Morris R. I., Metzger A. L., Bluestone R., Terasaki P. I. HL-A-W27--a useful discriminator in the arthropathies of inflammatory bowel disease. N Engl J Med. 1974 May 16;290(20):1117–1119. doi: 10.1056/NEJM197405162902004. [DOI] [PubMed] [Google Scholar]
  11. Rickert R. R., Carter H. W. The "early" ulcerative lesion of Crohn's disease: correlative light- and scanning electron-microscopic studies. J Clin Gastroenterol. 1980 Mar;2(1):11–19. [PubMed] [Google Scholar]
  12. Rosekrans P. C., Meijer C. J., van der Wal A. M., Cornelisse C. J., Lindeman J. Immunoglobulin containing cells in inflammatory bowel disease of the colon: a morphometric and immunohistochemical study. Gut. 1980 Nov;21(11):941–947. doi: 10.1136/gut.21.11.941. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Scott B. B., Goodall A., Stephenson P., Jenkins D. Rectal mucosal plasma cells in inflammatory bowel disease. Gut. 1983 Jun;24(6):519–524. doi: 10.1136/gut.24.6.519. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Skinner J. M., Whitehead R. The plasma cells in inflammatory disease of the colon: a quantitative study. J Clin Pathol. 1974 Aug;27(8):643–646. doi: 10.1136/jcp.27.8.643. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Stodell M. A., Butler R. C., Zemelman V. A., Henry K., Brewerton D. A. Increased numbers of IgG-containing cells in rectal lamina propria of patients with ankylosing spondylitis. Ann Rheum Dis. 1984 Apr;43(2):172–176. doi: 10.1136/ard.43.2.172. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. van Spreeuwel J. P., Duursma G. C., Meijer C. J., Bax R., Rosekrans P. C., Lindeman J. Campylobacter colitis: histological immunohistochemical and ultrastructural findings. Gut. 1985 Sep;26(9):945–951. doi: 10.1136/gut.26.9.945. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. van Spreeuwel J. P., Lindeman J., Meijer C. J. A quantitative study of immunoglobulin containing cells in the differential diagnosis of acute colitis. J Clin Pathol. 1985 Jul;38(7):774–777. doi: 10.1136/jcp.38.7.774. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES