Skip to main content
Gut logoLink to Gut
. 1989 Apr;30(4):528–534. doi: 10.1136/gut.30.4.528

Gall stones in a Danish population. Relation to weight, physical activity, smoking, coffee consumption, and diabetes mellitus.

T Jørgensen 1
PMCID: PMC1434027  PMID: 2785475

Abstract

The presence of gall stones diagnosed by ultrasonography in a cross sectional study was analysed in relation to relative weight, weight change since age 25, slimming treatment, physical activity, smoking, consumption of coffee, and diabetes mellitus. The random sample comprised 4581 men and women of Danish origin, aged 30, 40, 50, and 60 years, of whom 3608 (79%) attended the investigation. In women high body mass index, history of slimming treatment, and weight gain since the age of 25 of more than 5 body mass index units were each significantly associated with gall stones (p less than 0.05), while only body mass index was significant (p less than 0.05) in a multivariate analysis. In men history of slimming treatment was significantly associated (p less than 0.05) with gall stones in univariate and in multivariate analyses, where smoking also became significantly associated (p less than 0.05). No significant association was detected between gall stones and the other variables.

Full text

PDF
534

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Amaral J. F., Thompson W. R. Gallbladder disease in the morbidly obese. Am J Surg. 1985 Apr;149(4):551–557. doi: 10.1016/s0002-9610(85)80055-6. [DOI] [PubMed] [Google Scholar]
  2. Barbara L., Sama C., Morselli Labate A. M., Taroni F., Rusticali A. G., Festi D., Sapio C., Roda E., Banterle C., Puci A. A population study on the prevalence of gallstone disease: the Sirmione Study. Hepatology. 1987 Sep-Oct;7(5):913–917. doi: 10.1002/hep.1840070520. [DOI] [PubMed] [Google Scholar]
  3. Bennion L. J., Grundy S. M. Effects of diabetes mellitus on cholesterol metabolism in man. N Engl J Med. 1977 Jun 16;296(24):1365–1371. doi: 10.1056/NEJM197706162962401. [DOI] [PubMed] [Google Scholar]
  4. Braverman D. Z. The lack of effect of metoclopramide on gallbladder volume and contraction in diabetic cholecystoparesis. Am J Gastroenterol. 1986 Oct;81(10):960–962. [PubMed] [Google Scholar]
  5. Diehl A. K., Elford J. Gallstone disease in diabetics: analysis using multiple-cause mortality tables. Public Health. 1981 Sep;95(5):261–263. doi: 10.1016/s0033-3506(81)80016-9. [DOI] [PubMed] [Google Scholar]
  6. Diehl A. K., Stern M. P., Ostrower V. S., Friedman P. C. Prevalence of clinical gallbladder disease in Mexican-American, Anglo, and black women. South Med J. 1980 Apr;73(4):438-41, 443. doi: 10.1097/00007611-198004000-00012. [DOI] [PubMed] [Google Scholar]
  7. Friedman G. D., Kannel W. B., Dawber T. R. The epidemiology of gallbladder disease: observations in the Framingham Study. J Chronic Dis. 1966 Mar;19(3):273–292. doi: 10.1016/0021-9681(66)90132-9. [DOI] [PubMed] [Google Scholar]
  8. GITELSON S., SCHWARTZ A., FRAENKEL M., CHOWERS I. GALL-BLADDER DYSFUNCTION IN DIABETES MELLITUS: THE DIABETIC NEUROGENIC GALL BLADDER. Diabetes. 1963 Jul-Aug;12:308–312. doi: 10.2337/diab.12.4.308. [DOI] [PubMed] [Google Scholar]
  9. Garn S. M., LaVelle M., Rosenberg K. R., Hawthorne V. M. Maturational timing as a factor in female fatness and obesity. Am J Clin Nutr. 1986 Jun;43(6):879–883. doi: 10.1093/ajcn/43.6.879. [DOI] [PubMed] [Google Scholar]
  10. Haber G. B., Heaton K. W. Lipid composition of bile in diabetics and obesity-matched controls. Gut. 1979 Jun;20(6):518–522. doi: 10.1136/gut.20.6.518. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hanis C. L., Ferrell R. E., Tulloch B. R., Schull W. J. Gallbladder disease epidemiology in Mexican Americans in Starr County, Texas. Am J Epidemiol. 1985 Nov;122(5):820–829. doi: 10.1093/oxfordjournals.aje.a114165. [DOI] [PubMed] [Google Scholar]
  12. Honoré L. H. The lack of a positive association between symptomatic cholesterol cholelithiasis and clinical diabetes mellitus: a retrospective study. J Chronic Dis. 1980;33(8):465–469. doi: 10.1016/0021-9681(80)90071-5. [DOI] [PubMed] [Google Scholar]
  13. Janzon L., Aspelin P., Eriksson S., Hildell J., Trell E., Ostberg H. Ultrasonographic screening for gallstone disease in middle-aged women. Detection rate, symptoms, and biochemical features. Scand J Gastroenterol. 1985 Aug;20(6):706–710. doi: 10.3109/00365528509089199. [DOI] [PubMed] [Google Scholar]
  14. Jørgensen T. Gall stones in a Danish population: fertility period, pregnancies, and exogenous female sex hormones. Gut. 1988 Apr;29(4):433–439. doi: 10.1136/gut.29.4.433. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Jørgensen T. Gallstones in a Danish population: familial occurrence and social factors. J Biosoc Sci. 1988 Jan;20(1):111–120. doi: 10.1017/s0021932000017302. [DOI] [PubMed] [Google Scholar]
  16. Jørgensen T. Prevalence of gallstones in a Danish population. Am J Epidemiol. 1987 Nov;126(5):912–921. doi: 10.1093/oxfordjournals.aje.a114728. [DOI] [PubMed] [Google Scholar]
  17. Krotkiewski M., Björntorp P., Sjöström L., Smith U. Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution. J Clin Invest. 1983 Sep;72(3):1150–1162. doi: 10.1172/JCI111040. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Layde P. M., Vessey M. P., Yeates D. Risk factors for gall-bladder disease: a cohort study of young women attending family planning clinics. J Epidemiol Community Health. 1982 Dec;36(4):274–278. doi: 10.1136/jech.36.4.274. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. MANTEL N., HAENSZEL W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959 Apr;22(4):719–748. [PubMed] [Google Scholar]
  20. Prevalence of gallstone disease in an Italian adult female population. Rome Group for the Epidemiology and Prevention of Cholelithiasis (GREPCO). Am J Epidemiol. 1984 May;119(5):796–805. [PubMed] [Google Scholar]
  21. Scragg R. K., McMichael A. J., Baghurst P. A. Diet, alcohol, and relative weight in gall stone disease: a case-control study. Br Med J (Clin Res Ed) 1984 Apr 14;288(6424):1113–1119. doi: 10.1136/bmj.288.6424.1113. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Shreiner D. P., Sarva R. P., Van Thiel D., Yingvorapant N. Gallbladder function in diabetic patients. J Nucl Med. 1986 Mar;27(3):357–360. [PubMed] [Google Scholar]
  23. Stamford B. A., Matter S., Fell R. D., Sady S., Cresanta M. K., Papanek P. Cigarette smoking, physical activity, and alcohol consumption: relationship to blood lipids and lipoproteins in premenopausal females. Metabolism. 1984 Jul;33(7):585–590. doi: 10.1016/0026-0495(84)90053-2. [DOI] [PubMed] [Google Scholar]
  24. Thiet M. D., Mittelstaedt C. A., Herbst C. A., Jr, Buckwalter J. A. Cholelithiasis in morbid obesity. South Med J. 1984 Apr;77(4):415–417. doi: 10.1097/00007611-198404000-00002. [DOI] [PubMed] [Google Scholar]
  25. Thornton J. R., Heaton K. W., Macfarlane D. G. A relation between high-density-lipoprotein cholesterol and bile cholesterol saturation. Br Med J (Clin Res Ed) 1981 Nov 21;283(6303):1352–1354. doi: 10.1136/bmj.283.6303.1352. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Wattchow D. A., Hall J. C., Whiting M. J., Bradley B., Iannos J., Watts J. M. Prevalence and treatment of gall stones after gastric bypass surgery for morbid obesity. Br Med J (Clin Res Ed) 1983 Mar 5;286(6367):763–763. doi: 10.1136/bmj.286.6367.763. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Wheeler M., Hills L. L., Laby B. Cholelithiasis: a clinical and dietary survey. Gut. 1970 May;11(5):430–437. doi: 10.1136/gut.11.5.430. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Williams C. N., Johnston J. L. Prevalence of gallstones and risk factors in Caucasian women in a rural Canadian community. Can Med Assoc J. 1980 Mar 22;122(6):664–668. [PMC free article] [PubMed] [Google Scholar]
  29. Williams P. T., Wood P. D., Vranizan K. M., Albers J. J., Garay S. C., Taylor C. B. Coffee intake and elevated cholesterol and apolipoprotein B levels in men. JAMA. 1985 Mar 8;253(10):1407–1411. [PMC free article] [PubMed] [Google Scholar]
  30. Zahor A., Sternby N. H., Kagan A., Uemura K., Vanecek R., Vichert A. M. Frequency of cholelithiasis in Prague and Malmö. An autopsy study. Scand J Gastroenterol. 1974;9(1):3–7. [PubMed] [Google Scholar]
  31. de Leon M. P., Ferenderes R., Carulli N. Bile lipid composition and bile acid pool size in diabetes. Am J Dig Dis. 1978 Aug;23(8):710–716. doi: 10.1007/BF01072357. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES