Skip to main content
PMC home page
Gut logoLink to Gut
. 1986 Nov;27(11):1338–1346. doi: 10.1136/gut.27.11.1338

Changes in the gastric mucosa of the mouse associated with long lasting unsurmountable histamine H2 blockade.

D Poynter, S A Selway, S A Papworth, S R Riches
PMCID: PMC1434077  PMID: 2878860

Abstract

The oral administration of loxtidine to mice at doses of 600, 250, and 50 mg/kg/day for 746 days produced carcinoid tumours of the gastric fundus. The fundic mucosa also showed marked atypical hyperplasia with changes in foveolar cells similar to those seen in early incomplete metaplasia. These effects may be related to the prolonged achlorhydria produced by this potent unsurmountable histamine H2 receptor antagonist.

Full text

PDF
1343

Images in this article

1339Fig. 1
on p.1339
1340Fig. 2
on p.1340
1341Fig. 3
on p.1341
1342Fig. 4
on p.1342
1342Fig. 5
on p.1342
1343Fig. 6
on p.1343
1343Fig. 7
on p.1343
1344Fig. 8
on p.1344
1345Fig. 9
on p.1345
1345Fig. 10
on p.1345

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bishop A. E., Polak J. M., Facer P., Ferri G. L., Marangos P. J., Pearse A. G. Neuron specific enolase: a common marker for the endocrine cells and innervation of the gut and pancreas. Gastroenterology. 1982 Oct;83(4):902–915. [PubMed] [Google Scholar]
  2. Brettle R. P. Non-A, non-B hepatitis and intravenous immunoglobulin. Lancet. 1985 Jan 5;1(8419):51–51. doi: 10.1016/s0140-6736(85)91001-3. [DOI] [PubMed] [Google Scholar]
  3. Brittain R. T., Jack D., Reeves J. J., Stables R. Pharmacological basis for the induction of gastric carcinoid tumours in the rat by loxtidine, an insurmountable histamine H2-receptor blocking drug. Br J Pharmacol. 1985 Aug;85(4):843–847. doi: 10.1111/j.1476-5381.1985.tb11083.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Ekman L., Hansson E., Havu N., Carlsson E., Lundberg C. Toxicological studies on omeprazole. Scand J Gastroenterol Suppl. 1985;108:53–69. [PubMed] [Google Scholar]
  5. Elder J. B. Inhibition of acid and gastric carcinoids. Gut. 1985 Dec;26(12):1279–1283. doi: 10.1136/gut.26.12.1279. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Goldman H., Ming S. C. Fine structure of intestinal metaplasia and adenocarcinoma of the human stomach. Lab Invest. 1968 Feb;18(2):203–210. [PubMed] [Google Scholar]
  7. Jack D., Poynter D., Smith R. N. Antisecretory drugs and gastric cancer. Br Med J (Clin Res Ed) 1985 Sep 7;291(6496):675–675. doi: 10.1136/bmj.291.6496.675. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Larsson H., Carlsson E., Mattsson H., Lundell L., Sundler F., Sundell G., Wallmark B., Watanabe T., Håkanson R. Plasma gastrin and gastric enterochromaffinlike cell activation and proliferation. Studies with omeprazole and ranitidine in intact and antrectomized rats. Gastroenterology. 1986 Feb;90(2):391–399. doi: 10.1016/0016-5085(86)90938-8. [DOI] [PubMed] [Google Scholar]
  9. MILLER E. W., PYBUS F. C. Hyperplastic and neoplastic lesions of the glandular stomach and intestine in two inbred strains of mice and their reciprocal hybrids. Br J Cancer. 1956 Mar;10(1):89–109. doi: 10.1038/bjc.1956.13. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Ming S. C., Goldman H., Freiman D. G. Intestinal metaplasia and histogenesis of carcinoma in human stomach. Light and electron microscopic study. Cancer. 1967 Sep;20(9):1418–1429. doi: 10.1002/1097-0142(196709)20:9<1418::aid-cncr2820200908>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  11. Poynter D., Pick C. R., Harcourt R. A., Selway S. A., Ainge G., Harman I. W., Spurling N. W., Fluck P. A., Cook J. L. Association of long lasting unsurmountable histamine H2 blockade and gastric carcinoid tumours in the rat. Gut. 1985 Dec;26(12):1284–1295. doi: 10.1136/gut.26.12.1284. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Rowlatt C., Franks L. M., Sheriff M. U., Chesterman F. C. Naturally occurring tumors and other lesions of the digestive tract in untreated C57BL mice. J Natl Cancer Inst. 1969 Dec;43(6):1353–1364. [PubMed] [Google Scholar]
  13. Schoental R., Bensted J. P. Gastro-intestinal tumours in rats and mice following various routes of administration of N-methyl-N-nitroso-N'-nitroguanidine and N-ethyl-N-nitroso-N'-nitroguanidine. Br J Cancer. 1969 Dec;23(4):757–764. doi: 10.1038/bjc.1969.94. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Sheahan D. G., Jervis H. R. Comparative histochemistry of gastrointestinal mucosubstances. Am J Anat. 1976 Jun;146(2):103–131. doi: 10.1002/aja.1001460202. [DOI] [PubMed] [Google Scholar]
  15. Solcia E., Capella C., Buffa R., Usellini L., Frigerio B., Fontana P. Endocrine cells of the gastrointestinal tract and related tumors. Pathobiol Annu. 1979;9:163–204. [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES