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. 1989 May;30(5):686–690. doi: 10.1136/gut.30.5.686

Chronic colitis after Aeromonas infection.

J M Willoughby 1, A F Rahman 1, M M Gregory 1
PMCID: PMC1434198  PMID: 2731763

Abstract

Three patients with an acute colitis in which the only pathogen detected was either Aeromonas hydrophila or A sobria progressed to a chronic phase after the infection had been eliminated by antibiotic treatment in two and had resolved spontaneously in the third. The final diagnosis in each case was ulcerative colitis. Two of the patients have responded to anti-inflammatory medication but one has required panproctocolectomy. The sequence of symptoms and observations in these cases, as well as in others from the literature involving more familiar pathogens, suggests that bacterial infection may contribute to the development of chronic colitis. This supposition could be tested by extending the follow up of patients with acute infective colitis in a prospective multicentre trial.

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Selected References

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  1. ACHESON E. D., NEFZGER M. D. Ulcerative colitis in the United States Army in 1944. Epidemiology: comparisons between patients and controls. Gastroenterology. 1963 Jan;44:7–19. [PubMed] [Google Scholar]
  2. Annapurna E., Sanyal S. C. Enterotoxicity of Aeromonas hydrophila. J Med Microbiol. 1977 Aug;10(3):317–323. doi: 10.1099/00222615-10-3-317. [DOI] [PubMed] [Google Scholar]
  3. BANKS B. M., KORELITZ B. I., ZETZEL L. The course of nonspecific ulcerative colitis: review of twenty years' experience and late results. Gastroenterology. 1957 Jun;32(6):983–1012. [PubMed] [Google Scholar]
  4. Berk T., Gordon S. J., Choi H. Y., Cooper H. S. Cytomegalovirus infection of the colon: a possible role in exacerbations of inflammatory bowel disease. Am J Gastroenterol. 1985 May;80(5):355–360. [PubMed] [Google Scholar]
  5. Bernheimer A. W., Avigad L. S. Partial characterization of aerolysin, a lytic exotoxin from Aeromonas hydrophila. Infect Immun. 1974 Jun;9(6):1016–1021. doi: 10.1128/iai.9.6.1016-1021.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bolton R. P., Sherriff R. J., Read A. E. Clostridium difficile associated diarrhoea: a role in inflammatory bowel disease? Lancet. 1980 Feb 23;1(8165):383–384. doi: 10.1016/s0140-6736(80)90940-x. [DOI] [PubMed] [Google Scholar]
  7. Burke V., Robinson J., Berry R. J., Gracey M. Detection of enterotoxins of Aeromonas hydrophila by a suckling-mouse test. J Med Microbiol. 1981 Nov;14(4):401–408. doi: 10.1099/00222615-14-4-401. [DOI] [PubMed] [Google Scholar]
  8. Cumberbatch N., Gurwith M. J., Langston C., Sack R. B., Brunton J. L. Cytotoxic enterotoxin produced by Aeromonas hydrophila: relationship of toxigenic isolates to diarrheal disease. Infect Immun. 1979 Mar;23(3):829–837. doi: 10.1128/iai.23.3.829-837.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Donta S. T., Haddow A. D. Cytotoxic activity of Aeromonas hydrophila. Infect Immun. 1978 Sep;21(3):989–993. doi: 10.1128/iai.21.3.989-993.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Dronfield M. W., Fletcher J., Langman M. J. Coincident salmonella infections and ulcerative colitis: problems of recognition and management. Br Med J. 1974 Jan 19;1(5898):99–100. doi: 10.1136/bmj.1.5898.99. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. George W. L., Nakata M. M., Thompson J., White M. L. Aeromonas-related diarrhea in adults. Arch Intern Med. 1985 Dec;145(12):2207–2211. [PubMed] [Google Scholar]
  12. Goodman M. J., Pearson K. W., McGhie D., Dutt S., Deodhar S. G. Campylobacter and Giardia lamblia causing exacerbation of inflammatory bowel disease. Lancet. 1980 Dec 6;2(8206):1247–1247. doi: 10.1016/s0140-6736(80)92504-0. [DOI] [PubMed] [Google Scholar]
  13. Gracey M., Burke V., Robinson J. Aeromonas-associated gastroenteritis. Lancet. 1982 Dec 11;2(8311):1304–1306. doi: 10.1016/s0140-6736(82)91510-0. [DOI] [PubMed] [Google Scholar]
  14. LaMont J. T., Trnka Y. M. Therapeutic implications of Clostridium difficile toxin during relapse of chronic inflammatory bowel disease. Lancet. 1980 Feb 23;1(8165):381–383. doi: 10.1016/s0140-6736(80)90939-3. [DOI] [PubMed] [Google Scholar]
  15. Lawson M. A., Burke V., Chang B. J. Invasion of HEp-2 cells by fecal isolates of Aeromonas hydrophila. Infect Immun. 1985 Mar;47(3):680–683. doi: 10.1128/iai.47.3.680-683.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Lindeman R. J., Weinstein L., Levitan R., Patterson J. F. Ulcerative colitis and intestinal salmonellosis. Am J Med Sci. 1967 Dec;254(6):855–861. doi: 10.1097/00000441-196712000-00014. [DOI] [PubMed] [Google Scholar]
  17. Ljungh A., Eneroth P., Wadström T. Cytotonic enterotoxin from Aeromonas hydrophila. Toxicon. 1982;20(4):787–794. doi: 10.1016/0041-0101(82)90126-x. [DOI] [PubMed] [Google Scholar]
  18. Newman A., Lambert J. R. Campylobacter jejuni causing flare-up in inflammatory bowel disease. Lancet. 1980 Oct 25;2(8200):919–919. doi: 10.1016/s0140-6736(80)92078-4. [DOI] [PubMed] [Google Scholar]
  19. Pokorney B. H., Nichols T. W., Jr Pseudomembranous colitis. A complication of sulfasalazine therapy in a patient with Crohn's colitis. Am J Gastroenterol. 1981 Oct;76(4):374–376. [PubMed] [Google Scholar]
  20. ROSNER R. AEROMONAS HYDROPHILA AS THE ETIOLOGIC AGENT IN A CASE OF SEVERE GASTROENTERITIS. Am J Clin Pathol. 1964 Oct;42:402–404. doi: 10.1093/ajcp/42.4.402. [DOI] [PubMed] [Google Scholar]
  21. Rahman A. F., Willoughby J. M. Dysentery-like syndrome associated with Aeromonas hydrophila. Br Med J. 1980 Oct 11;281(6246):976–976. doi: 10.1136/bmj.281.6246.976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Sanyal S. C., Singh S. J., Sen P. C. Enteropathogenicity of Aeromonas hydrophila and Plesiomonas shigelloides. J Med Microbiol. 1975 Feb;8(1):195–198. doi: 10.1099/00222615-8-1-195. [DOI] [PubMed] [Google Scholar]
  23. Treacher D. F., Jewell D. P. Yersinia colitis associated with Crohn's disease. Postgrad Med J. 1985 Feb;61(712):173–174. doi: 10.1136/pgmj.61.712.173. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Von Graevenitz A., Mensch A. H. The genus aeromonas in human bacteriology report of 30 cases and review of the literature. N Engl J Med. 1968 Feb 1;278(5):245–249. doi: 10.1056/NEJM196802012780504. [DOI] [PubMed] [Google Scholar]
  25. Wadström T., Aust-Kettis A., Habte D., Holmgren J., Meeuwisse G., Möllby R., Söderlind O. Enterotoxin-producing bacteria and parasites in stools of Ethiopian children with diarrhoeal disease. Arch Dis Child. 1976 Nov;51(11):865–870. doi: 10.1136/adc.51.11.865. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Watson I. M., Robinson J. O., Burke V., Gracey M. Invasiveness of Aeromonas spp. in relation to biotype, virulence factors, and clinical features. J Clin Microbiol. 1985 Jul;22(1):48–51. doi: 10.1128/jcm.22.1.48-51.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. von Graevenitz A., Zinterhofer L. The detection of Aeromonas hydrophila in stool specimens. Health Lab Sci. 1970 Jul;7(3):124–127. [PubMed] [Google Scholar]

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