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. 1989 May;30(5):569–572. doi: 10.1136/gut.30.5.569

Endoscopic and gastric acid studies in homozygous sickle cell disease and upper abdominal pain.

M G Lee 1, C H Thirumalai 1, S I Terry 1, G R Serjeant 1
PMCID: PMC1434224  PMID: 2731748

Abstract

Upper endoscopic and gastric acid output studies were done in 51 patients with homozygous sickle cell (SS) disease and recurrent epigastric pain. Twenty (39%) had abnormalities in the upper gastrointestinal tract including 18 (35%) with peptic ulcers. Mean basal and maximum acid output were similar in patients with and without duodenal ulcer (DU). Because DU in SS disease does not appear to be associated with high acid outputs observed in other populations, it may reflect reduced mucosal resistance, possibly resulting from ischaemia. This hypothesis was supported by the significantly lower fetal haemoglobin level among SS-DU patients.

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Selected References

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  1. Lam S. K., Hasan M., Sircus W., Wong J., Ong G. B., Prescott R. J. Comparison of maximal acid output and gastrin response to meals in Chinese and Scottish normal and duodenal ulcer subjects. Gut. 1980 Apr;21(4):324–328. doi: 10.1136/gut.21.4.324. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. MARGOLIES M. P. Sickle cell anemia; a composite study and survey. Medicine (Baltimore) 1951 Dec;30(4):357–433. doi: 10.1097/00005792-195112000-00003. [DOI] [PubMed] [Google Scholar]
  3. Menguy R. Pathophysiology of peptic ulcer. Am J Surg. 1970 Sep;120(3):282–288. doi: 10.1016/s0002-9610(70)80200-8. [DOI] [PubMed] [Google Scholar]
  4. Serjeant G. R., Grandison Y., Lowrie Y., Mason K., Phillips J., Serjeant B. E., Vaidya S. The development of haematological changes in homozygous sickle cell disease: a cohort study from birth to 6 years. Br J Haematol. 1981 Aug;48(4):533–543. doi: 10.1111/j.1365-2141.1981.tb02750.x. [DOI] [PubMed] [Google Scholar]
  5. Serjeant G. R., May H., Patrick A., Slifer E. D. Duodenal ulceration in sickle cell anaemia. Trans R Soc Trop Med Hyg. 1973;67(1):59–63. doi: 10.1016/0035-9203(73)90321-0. [DOI] [PubMed] [Google Scholar]
  6. Serjeant G. R., Richards R., Barbor P. R., Milner P. F. Relatively benign sickle-cell anaemia in 60 patients aged over 30 in the West Indies. Br Med J. 1968 Jul 13;3(5610):86–91. doi: 10.1136/bmj.3.5610.86. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Tovey F. Peptic ulcer in India and Bangladesh. Gut. 1979 Apr;20(4):329–347. doi: 10.1136/gut.20.4.329. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Veselý K. T., Kubícková Z., Dvoráková M. Clinical data and characteristics differentiating types of peptic ulcer. Gut. 1968 Feb;9(1):57–68. doi: 10.1136/gut.9.1.57. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Wosornu L., Konotey-Ahulu F. I. Gastric acid secretion in sickle-cell anaemia. Gut. 1971 Mar;12(3):197–199. doi: 10.1136/gut.12.3.197. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. ZARAFONETIS C. J., JOSEPH R. R., McMASTER J. D., KALAS J. P. Osmolarity of gastric secretions in sicklemic individuals. J Lab Clin Med. 1961 Apr;57:600–603. [PubMed] [Google Scholar]

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