Skip to main content
PMC home page
Gut logoLink to Gut
. 1989 Oct;30(10):1334–1338. doi: 10.1136/gut.30.10.1334

Patterns of colonisation of Campylobacter pylori in the oesophagus, stomach and duodenum.

S J Walker 1, P J Birch 1, M Stewart 1, C J Stoddard 1, C A Hart 1, D W Day 1
PMCID: PMC1434412  PMID: 2583561

Abstract

Thirty five subjects underwent upper gastrointestinal endoscopy and multiple biopsy (30 patients, five normal subjects). A total of 11 biopsies per subject from four sites (oesophagus (three), gastric body (two), antrum (three), duodenum (three] were examined for inflammation and the presence of Campylobacter pylori and using standard methods of culture and by light (LM) and electron microscopy (EM). The organism was cultured from oesophageal biopsies in eight of 30 (27%) patients but could not be identified at this site by LM or EM. There was evidence of oesophageal inflammation in 20 patients which was associated with the local finding of C pylori in five (25%) including two of seven (29%) with Barrett's mucosa. Antral C pylori was present in 22 of 23 (96%) patients with chronic active gastritis. The organism was found in the antrum and oesophagus in four of 22 patients (18%), in the antrum and duodenum in four of 22 patients (18%) and in all three sites in a further two of 22 patients (9%). Antral C pylori was found in five of six patients with peptic ulceration. C pylori was cultured from the duodenum in six patients with confirmation by LN and EM in three, but only on areas of gastric metaplasia. The organism was not found in the normal group. This study indicates that C pylori may be irregularly isolated from the oesophagus and duodenum in patients with antral C pylori and chronic active gastritis. The role of C pylori in the oesophagus is most likely that of a commensal or contaminant.

Full text

PDF
1338

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Borkent M. V., Beker J. A. Treatment of ulcerative reflux oesophagitis with colloidal bismuth subcitrate in combination with cimetidine. Gut. 1988 Mar;29(3):385–389. doi: 10.1136/gut.29.3.385. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Buck G. E., Gourley W. K., Lee W. K., Subramanyam K., Latimer J. M., DiNuzzo A. R. Relation of Campylobacter pyloridis to gastritis and peptic ulcer. J Infect Dis. 1986 Apr;153(4):664–669. doi: 10.1093/infdis/153.4.664. [DOI] [PubMed] [Google Scholar]
  3. Campylobacter-like organisms in the stomach of patients and healthy individuals. Lancet. 1984 Jun 16;1(8390):1348–1349. [PubMed] [Google Scholar]
  4. Flook D., Stoddard C. J. Gastro-oesophageal reflux and oesophagitis before and after vagotomy for duodenal ulcer. Br J Surg. 1985 Oct;72(10):804–807. doi: 10.1002/bjs.1800721010. [DOI] [PubMed] [Google Scholar]
  5. Gastric spiral bacteria. Lancet. 1984 Jul 14;2(8394):100–101. [PubMed] [Google Scholar]
  6. Gray S. F., Wyatt J. I., Rathbone B. J. Simplified techniques for identifying Campylobacter pyloridis. J Clin Pathol. 1986 Nov;39(11):1279–1279. doi: 10.1136/jcp.39.11.1279-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hazell S. L., Lee A., Brady L., Hennessy W. Campylobacter pyloridis and gastritis: association with intercellular spaces and adaptation to an environment of mucus as important factors in colonization of the gastric epithelium. J Infect Dis. 1986 Apr;153(4):658–663. doi: 10.1093/infdis/153.4.658. [DOI] [PubMed] [Google Scholar]
  8. Humphreys H., Bourke S., Dooley C., McKenna D., Power B., Keane C. T., Sweeney E. C., O'Moráin C. Effect of treatment on Campylobacter pylori in peptic disease: a randomised prospective trial. Gut. 1988 Mar;29(3):279–283. doi: 10.1136/gut.29.3.279. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Johnston B. J., Reed P. I., Ali M. H. Campylobacter like organisms in duodenal and antral endoscopic biopsies: relationship to inflammation. Gut. 1986 Oct;27(10):1132–1137. doi: 10.1136/gut.27.10.1132. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Jones D. M., Lessells A. M., Eldridge J. Campylobacter like organisms on the gastric mucosa: culture, histological, and serological studies. J Clin Pathol. 1984 Sep;37(9):1002–1006. doi: 10.1136/jcp.37.9.1002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Marshall B. J., McGechie D. B., Rogers P. A., Glancy R. J. Pyloric Campylobacter infection and gastroduodenal disease. Med J Aust. 1985 Apr 15;142(8):439–444. doi: 10.5694/j.1326-5377.1985.tb113444.x. [DOI] [PubMed] [Google Scholar]
  12. McNulty C. A. Campylobacter pyloridis-associated gastritis. J Infect. 1986 Sep;13(2):107–113. doi: 10.1016/s0163-4453(86)92757-x. [DOI] [PubMed] [Google Scholar]
  13. McNulty C. A., Gearty J. C., Crump B., Davis M., Donovan I. A., Melikian V., Lister D. M., Wise R. Campylobacter pyloridis and associated gastritis: investigator blind, placebo controlled trial of bismuth salicylate and erythromycin ethylsuccinate. Br Med J (Clin Res Ed) 1986 Sep 13;293(6548):645–649. doi: 10.1136/bmj.293.6548.645. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. O'Connor H. J., Dixon M. F., Wyatt J. I., Axon A. T., Ward D. C., Dewar E. P., Johnston D. Effect of duodenal ulcer surgery and enterogastric reflux on Campylobacter pyloridis. Lancet. 1986 Nov 22;2(8517):1178–1181. doi: 10.1016/s0140-6736(86)92193-8. [DOI] [PubMed] [Google Scholar]
  15. Paull A., Trier J. S., Dalton M. D., Camp R. C., Loeb P., Goyal R. K. The histologic spectrum of Barrett's esophagus. N Engl J Med. 1976 Aug 26;295(9):476–480. doi: 10.1056/NEJM197608262950904. [DOI] [PubMed] [Google Scholar]
  16. Paull G., Yardley J. H. Gastric and esophageal Campylobacter pylori in patients with Barrett's esophagus. Gastroenterology. 1988 Jul;95(1):216–218. doi: 10.1016/0016-5085(88)90316-2. [DOI] [PubMed] [Google Scholar]
  17. Price A. B., Levi J., Dolby J. M., Dunscombe P. L., Smith A., Clark J., Stephenson M. L. Campylobacter pyloridis in peptic ulcer disease: microbiology, pathology, and scanning electron microscopy. Gut. 1985 Nov;26(11):1183–1188. doi: 10.1136/gut.26.11.1183. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Rathbone B. J., Wyatt J. I., Heatley R. V. Campylobacter pyloridis--a new factor in peptic ulcer disease? Gut. 1986 Jun;27(6):635–641. doi: 10.1136/gut.27.6.635. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Steer H. W. Surface morphology of the gastroduodenal mucosa in duodenal ulceration. Gut. 1984 Nov;25(11):1203–1210. doi: 10.1136/gut.25.11.1203. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet. 1983 Jun 4;1(8336):1273–1275. [PubMed] [Google Scholar]
  21. Venables C. W. Mucus, pepsin, and peptic ulcer. Gut. 1986 Mar;27(3):233–238. doi: 10.1136/gut.27.3.233. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Walker S. J., Murray A. E. A review of Campylobacter pylori in upper gastrointestinal disease. Br J Hosp Med. 1988 Jul;40(1):27, 30-6. [PubMed] [Google Scholar]
  23. Wyatt J. I., Rathbone B. J., Dixon M. F., Heatley R. V. Campylobacter pyloridis and acid induced gastric metaplasia in the pathogenesis of duodenitis. J Clin Pathol. 1987 Aug;40(8):841–848. doi: 10.1136/jcp.40.8.841. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES