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. 1984 Dec;46(6):831–835. doi: 10.1016/S0006-3495(84)84082-5

Saturation behavior of single, amiloride-sensitive Na+ channels in planar lipid bilayers.

L Olans, S Sariban-Sohraby, D J Benos
PMCID: PMC1435104  PMID: 6097320

Abstract

Single epithelial Na+ channels incorporated into planar lipid bilayers were studied to determine the effects of Na concentration on its own conductance. Amiloride-sensitive Na+ channels were obtained from apical membrane vesicles made from A6 cells, a continuous epithelial cell-line derived from amphibian kidney. Single-channel conductance was found to be a saturable function of Na+ concentration, with a Michaelis constant of approximately 17 or 47 mM, for a Gmax of approximately 4 or 44 pS, respectively.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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