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. 1984 Jan;45(1):187–198. doi: 10.1016/S0006-3495(84)84147-8

Single-channel currents from acetylcholine receptors in embryonic chick muscle. Kinetic and conductance properties of gaps within bursts.

A Auerbach, F Sachs
PMCID: PMC1435280  PMID: 6324902

Abstract

In tissue-cultured chick muscle, bursts of current from single nicotinic ion channels contain a variety of low-conductance gaps. One population has a lifetime of approximately 0.1 ms and an unknown conductance. A second population has a lifetime of 2-10 ms and conductance of zero. The third population has a lifetime of 0.5-1 ms and a mean conductance approximately 2% that of the main conductance state. This subconductance state has an agonist-dependent lifetime, longer for suberyldicholine than for acetylcholine, and is liganded to the same extent as the main conductance state. Subconductance gaps have a linear current-voltage behavior in the range -60 to -140 mV and appear to have the same reversal potential as the main state. The subconductance state is composed of a group of states which interconvert with correlation times longer than 300 microseconds.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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