Skip to main content
PMC home page
British Medical Journal (Clinical Research Ed.) logoLink to British Medical Journal (Clinical Research Ed.)
. 1984 Feb 4;288(6414):360–361. doi: 10.1136/bmj.288.6414.360

Measurement of serum amyloid A protein concentrations as test of renal allograft rejection in patients with initially non-functioning grafts.

C P Maury, A M Teppo, J Ahonen, E von Willebrand
PMCID: PMC1444265  PMID: 6419926

Abstract

Serum amyloid A protein concentrations were monitored in 10 renal transplant recipients who required dialysis after transplantation because of an initially non-functioning graft. Fifteen rejection episodes were identified by repeated fine needle aspiration biopsies of the grafts. All rejections were characterised by pronounced increases in serum amyloid A concentrations, the mean peak value being 363 (SE 57) mg/1 as compared with a mean preoperative concentration of 14 (5) mg/1. The rise in concentrations preceded the start of anti-rejection treatment by an average of 2.5 days in eight of the rejection episodes, in five episodes it occurred the same day, and in two episodes it occurred the next day. With exclusion of the predictable surgery induced rise in values, which peaked on the second postoperative day, there were 17 increases in amyloid A concentrations peaking at greater than or equal to 100 mg/1; in two cases they were not related to documented rejection. These findings show that measurements of serum amyloid A concentration provide a valuable non-invasive aid in identifying acute renal allograft rejection, including that in patients whose graft does not function initially.

Full text

PDF
360

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Benditt E. P., Eriksen N. Amyloid protein SAA is associated with high density lipoprotein from human serum. Proc Natl Acad Sci U S A. 1977 Sep;74(9):4025–4028. doi: 10.1073/pnas.74.9.4025. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. De Beer F. C., Mallya R. K., Fagan E. A., Lanham J. G., Hughes G. R., Pepys M. B. Serum amyloid-A protein concentration in inflammatory diseases and its relationship to the incidence of reactive systemic amyloidosis. Lancet. 1982 Jul 31;2(8292):231–234. doi: 10.1016/s0140-6736(82)90321-x. [DOI] [PubMed] [Google Scholar]
  3. Falck H. M., Maury C. P., Teppo A. M., Wegelius O. Correlation of persistently high serum amyloid A protein and C-reactive protein concentrations with rapid progression of secondary amyloidosis. Br Med J (Clin Res Ed) 1983 Apr 30;286(6375):1391–1393. doi: 10.1136/bmj.286.6375.1391. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Häyry P., von Willebrand E., Ahonen J., Eklund B. Glucocorticosteroids in renal transplantation. I. Impact of high- versus low-dose post-operative methylprednisolone administration on the first episode(s) of rejection. Scand J Immunol. 1982 Jul;16(1):39–49. doi: 10.1111/j.1365-3083.1982.tb00697.x. [DOI] [PubMed] [Google Scholar]
  5. Häyry P., von Willebrand E. Monitoring of human renal allograft rejection with fine-needle aspiration cytology. Scand J Immunol. 1981;13(1):87–97. doi: 10.1111/j.1365-3083.1981.tb00114.x. [DOI] [PubMed] [Google Scholar]
  6. Maury C. P., Teppo A. M., Eklund B., Häyry P., Ahonen J. Serum amyloid A levels in human renal allograft rejection. Clin Sci (Lond) 1983 Nov;65(5):547–550. doi: 10.1042/cs0650547. [DOI] [PubMed] [Google Scholar]
  7. Maury C. P., Teppo A. M., Salaspuro M. P. Amyloid A fibril degrading activity in serum in liver disease--relation to serum acute phase and other protein levels. Clin Chim Acta. 1983 Jun 30;131(1-2):29–37. doi: 10.1016/0009-8981(83)90349-2. [DOI] [PubMed] [Google Scholar]
  8. McAdam K. P., Elin R. J., Sipe J. D., Wolff S. M. Changes in human serum amyloid A and C-reactive protein after etiocholanolone-induced inflammation. J Clin Invest. 1978 Feb;61(2):390–394. doi: 10.1172/JCI108949. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. McAdam K. P., Li J., Knowles J., Foss N. T., Dinarello C. A., Rosenwasser L. J., Selinger M. J., Kaplan M. M., Goodman R., Herbert P. N. The biology of SAA: identification of the inducer, in vitro synthesis, and heterogeneity demonstrated with monoclonal antibodies. Ann N Y Acad Sci. 1982;389:126–136. doi: 10.1111/j.1749-6632.1982.tb22131.x. [DOI] [PubMed] [Google Scholar]
  10. Morrow J. F., Stearman R. S., Peltzman C. G., Potter D. A. Induction of hepatic synthesis of serum amyloid A protein and actin. Proc Natl Acad Sci U S A. 1981 Aug;78(8):4718–4722. doi: 10.1073/pnas.78.8.4718. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Pasternack A., Virolainen M., Häyry P. Fine-needle aspiration biopsy in the diagnosis of human renal allograft rejection. J Urol. 1973 Feb;109(2):167–172. doi: 10.1016/s0022-5347(17)60380-x. [DOI] [PubMed] [Google Scholar]
  12. Sipe J. D., Vogel S. N., Ryan J. L., McAdam K. P., Rosenstreich D. L. Detection of a mediator derived from endotoxin-stimulated macrohpages that induces the acute phase serum amyloid A response in mice. J Exp Med. 1979 Sep 19;150(3):597–606. doi: 10.1084/jem.150.3.597. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Medical Journal (Clinical research ed.) are provided here courtesy of BMJ Publishing Group

RESOURCES