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. 1976 May;30(5):769–777.

The natural heterohaemagglutinin in the serum of the toad Bufo regularis, and its relationship to lower vertebrate immunoglobulins.

P Balding, E R Gold
PMCID: PMC1445037  PMID: 58835

Abstract

The serum of the toad Bufo regularis contains a natural heterohaemagglutinin for human erythrocytes, Which appears to have anti-(B + HP) specificity. Results of inhibition and absorption experiments indicate that only one agglutinin is present. The biochemical specificity of the agglutinin may be provisionally described as involving alpha-D-galactose residues linked (1-3) in the B determinant, of red cells possessing the H ANTIGEN. Unlike amphibian IgM, the agglutinin was insensitive to 2-mercaptoethanol treatment; moreover, it could be eluted from the alpha1 globulin region on cellulose acetate electrophoresis. These results suggest that this naturally occurring heterohaemagglutinin has a structure similar to that of plant and animal lectins. The relationship of this observation to the phylogenetic evolution of immunity is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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