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. 1977 Dec;33(6):817–825.

Macrophage-induced thymic lymphocyte maturation.

J G Van den Tweel, W S Walker
PMCID: PMC1445550  PMID: 304037

Abstract

Guinea-pig peritoneal macrophages were found to influence the functional maturation of thymic lymphocytes. Autologous thymic lymphocytes obtained from macrophage co-cultures responded to three different mitogens and were reduced in their ability to reassociate spontaneously with macrophages. Neither of these properties were found in thymic lymphocytes that had not been cultured with macrophages. These functional changes appeared to be specific for macrophages since thymic lymphocytes incubated with skin fibroblasts failed to respond to the test mitogens. Furthermore, they were not the result of either the inactivation, by macrophages, of a putative suppressor thymocyte or a soluble macrophage product. In addition to influencing the functional maturation of thymic lymphocytes, macrophages also appeared to play a direct role in inducing the mitogen response of functionally mature cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Borella L., Webster R. G. The immunosuppressive effects of long-term combination chemotherapy in children with acute leukemia in remission. Cancer Res. 1971 Apr;31(4):420–426. [PubMed] [Google Scholar]
  2. Demus A., Walker W. S., Borella L. Function of surface-adherent cells in the induction of the human mixed leucocyte reaction. I. The transient surface adherence of responding lymphocytes in the human mixed leucocyte response. Clin Exp Immunol. 1974 Nov;18(3):337–346. [PMC free article] [PubMed] [Google Scholar]
  3. Ellner J. J., Lipsky P. E., Rosenthal A. S. Phytohemagglutinin-induced proliferation of guinea pig thymus-derived lymphocytes. II. Accessory cell function. J Immunol. 1976 Mar;116(3):876–880. [PubMed] [Google Scholar]
  4. Gery I., Waksman B. H. Potentiation of the T-lymphocyte response to mitogens. II. The cellular source of potentiating mediator(s). J Exp Med. 1972 Jul 1;136(1):143–155. doi: 10.1084/jem.136.1.143. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Lipsky P. E., Ellner J. J., Rosenthal A. L. Phytohemagglutinin-induced proliferation of guinea pig thymus-derived lymphocytes. I. Accessory cell dependence. J Immunol. 1976 Mar;116(3):868–875. [PubMed] [Google Scholar]
  6. Lipsky P. E., Rosenthal A. S. Macrophage-lymphocyte interaction. I. Characteristics of the antigen-independent-binding of guinea pig thymocytes and lymphocytes to syngeneic macrophages. J Exp Med. 1973 Oct 1;138(4):900–924. doi: 10.1084/jem.138.4.900. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Lipsky P. E., Rosenthal A. S. Macrophage-lymphocyte interaction: antigen-independent binding of guinea pig lymph node lymphocytes by macrophages. J Immunol. 1975 Aug;115(2):440–445. [PubMed] [Google Scholar]
  8. Mills G., Monticone V., Paetkau The role of macrophages in thymocyte mitogenesis. J Immunol. 1976 Oct;117(4):1325–1330. [PubMed] [Google Scholar]
  9. Mosier D. E., Pierce C. W. Functional maturation of thymic lymphocyte populations in vitro. J Exp Med. 1972 Dec 1;136(6):1484–1500. doi: 10.1084/jem.136.6.1484. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Oppenheim J. J., Leventhal B. G., Hersh E. M. The transformation of column-purified lymphocytes with nonspecific and specific antigenic stimuli. J Immunol. 1968 Aug;101(2):262–267. [PubMed] [Google Scholar]
  11. Siegel I. Natural and antibody-induced adherence of guinea pig phagocytic cells to autologous and heterologous thymocytes. J Immunol. 1970 Oct;105(4):879–885. [PubMed] [Google Scholar]
  12. Stobo J. D., Paul W. E. Functional heterogeneity of murine lymphoid cells. II. Acquisition of mitogen responsiveness and of theta antigen during the ontogeny of thymocytes and "T" lymphocytes. Cell Immunol. 1972 Aug;4(4):367–380. doi: 10.1016/0008-8749(72)90039-1. [DOI] [PubMed] [Google Scholar]
  13. Trainin N. Thymic hormones and the immune response. Physiol Rev. 1974 Apr;54(2):272–315. doi: 10.1152/physrev.1974.54.2.272. [DOI] [PubMed] [Google Scholar]
  14. Yoshinaga M., Nakamura S., Hayashi H. Interaction between lymphocytes and inflammatory exudate cells. I. Enhacement of thymocyte response to PHA by product(s) of polymorphonuclear leukocytes and macrophages. J Immunol. 1975 Aug;115(2):533–538. [PubMed] [Google Scholar]

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