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. 1975 Jun;28(6):1007–1013.

Immunodeficiency in the chicken. I. Disparity in suppression of antibody responses to various antigens following surgical bursectomy.

J Ivanyi
PMCID: PMC1445893  PMID: 166036

Abstract

The extent of suppression of antibody response by bursectomy (Bx) was examined as a measure of the seeding sequence of different clones from the bursa to peripheral lymphoid tissues. Chickens were bursectomized surgically 1, 4 or 7 days after hatching and immunized later with four antigens: sheep red blood cells (SRBC); Bordetella pertussis (Bp); human serum albumin (HSA); influenza virus (IV). The kinetics of the antibody responses were delayed in bursectomized birds when compared with the control groups. The following order in the degree of immunosuppression was established: Bp greater than HSA greater than SRBC greater than IV. This is discussed in relation to the 'sequential maturation' theory of ontogenesis of immunocyte differentiation. The data also stress the limitation of non-specific markers for assessing partial immunodeficiency states.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Argyris B. F. Role of macrophages in immunological maturation. J Exp Med. 1968 Sep 1;128(3):459–467. doi: 10.1084/jem.128.3.459. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Arrenbrecht S. Normal development of the thymus-dependent limb of humoral immune responses in mice. Eur J Immunol. 1973 Aug;3(8):506–511. doi: 10.1002/eji.1830030811. [DOI] [PubMed] [Google Scholar]
  3. Carter B. G., Rector E. S. The generation of antigen sensitive cells in the newborn mouse. J Immunol. 1972 Dec;109(6):1345–1351. [PubMed] [Google Scholar]
  4. Chiscon M. Q., Golub E. S. Functional development of the interacting cells in the immune response. I. Development of T cell and B cell function. J Immunol. 1972 May;108(5):1379–1386. [PubMed] [Google Scholar]
  5. Ford W. L., Gowans J. L. The role of lymphocytes in antibody formation. II. The influence of lymphocyte migration on the initiation of antibody formation in the isolated, perfused spleen. Proc R Soc Lond B Biol Sci. 1967 Sep 12;168(1012):244–262. doi: 10.1098/rspb.1967.0064. [DOI] [PubMed] [Google Scholar]
  6. Ivanyi J. Sequential recruitment of antibody class-committed B lymphocytes during ontogeny. Eur J Immunol. 1973 Dec;3(12):789–793. doi: 10.1002/eji.1830031210. [DOI] [PubMed] [Google Scholar]
  7. Iványi J., Marvanova H., Skamene E. Immunoglobulin synthesis and lymphocyte transformation by anti-immunoglobulin sera in bursectomized chickens. Immunology. 1969 Sep;17(3):325–331. [PMC free article] [PubMed] [Google Scholar]
  8. Iványi J., Valentová V., Cerný J. The dose of antigen required for the suppression of the IgM and IgG antibody response in chickens. I. The kinetics and characterization of serum antibodies. Folia Biol (Praha) 1966;12(3):157–167. [PubMed] [Google Scholar]
  9. Kincade P. W., Cooper M. D. Development and distribution of immunoglobulin-containing cells in the chicken. An immunofluorescent analysis using purified antibodies to mu, gamma and light chains. J Immunol. 1971 Feb;106(2):371–382. [PubMed] [Google Scholar]
  10. Lafleur L., Miller R. G., Phillips R. A. A quantitative assay for the progenitors of bone marrow-associated lymphocytes. J Exp Med. 1972 Jun 1;135(6):1363–1374. doi: 10.1084/jem.135.6.1363. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Leiper J. B. Ontogeny of haemolytic plaque-forming cells in newborn rabbit's spleen in response to different erythrocyte antigens. Immunology. 1974 May;26(5):1061–1067. [PMC free article] [PubMed] [Google Scholar]
  12. Makinodan T., Albright J. F. Proliferative and differentiative manifestations of cellular immune potential. Prog Allergy. 1967;10:1–36. [PubMed] [Google Scholar]
  13. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  14. Press J. L., Klinman N. R. Enumeration and analysis of antibody-forming cell precursors in the neonatal mouse. J Immunol. 1973 Sep;111(3):829–835. [PubMed] [Google Scholar]
  15. Spear P. G., Wang A. L., Rutishauser U., Edelman G. M. Characterization of splenic lymphoid cells in fetal and newborn mice. J Exp Med. 1973 Sep 1;138(3):557–573. doi: 10.1084/jem.138.3.557. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Yung L. L., Wyn-Evans T. C., Diener E. Ontogeny of the murine immune system: development of antigen recognition and immune responsiveness. Eur J Immunol. 1973 Apr;3(4):224–228. doi: 10.1002/eji.1830030409. [DOI] [PubMed] [Google Scholar]

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