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. 1986 May;58(1):51–56.

Helper and suppressor activities of an autoreactive mouse thyroglobulin-specific T-cell clone.

B R Champion, P Hutchings, S Davies, S Marshall-Clarke, A Cooke, I M Roitt
PMCID: PMC1452646  PMID: 2940170

Abstract

An autoreactive T-cell clone, MTg9B3, specific for mouse thyroglobulin, has been characterized. This clone has properties consistent with it an being autoreactive T helper cell. It is I-A restricted, with a surface phenotype of Thy 1+, L3T4+, Ly2-, and produces a number of non-specific lymphokine activities following specific triggering with antigen. Furthermore, antigen-stimulated clone cells were capable of providing bystander help in SRBC-specific antibody responses. Surprisingly, MTg9B3 cells had a profound suppressive effect on thyroglobulin autoantibody responses in vitro.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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