Skip to main content
PMC home page
Immunology logoLink to Immunology
. 1987 Jul;61(3):297–301.

Variable effects of dengue virus-induced cytotoxic factors on different subpopulations of macrophages.

U C Chaturvedi, R Nagar, L Gulati, A Mathur
PMCID: PMC1453398  PMID: 3497088

Abstract

Dengue virus (DV) induces T lymphocytes of the spleen to produce a cytotoxic factor (CF) that induces a subpopulation of macrophages (M phi) to produce a soluble cytotoxin (CF2). Both these factors kill normal lymphoid cells and M phi. The present study was undertaken to investigate the effects of these factors on the I-A-positive and I-A-negative subpopulations of mouse peritoneal M phi. It was observed that CF kills I-A-negative M phi and induces I-A-positive M phi to produce the CF2 that kills both types of cells. However, even when combined together, CF and CF2 do not kill 100% of the M phi. The two-step mechanism involving co-operation between T cells and M phi appears to be biologically economical for maintaining the cytotoxic pathway.

Full text

PDF
297

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aksamit R. R., Kim K. J. Macrophage cell lines produce a cytotoxin. J Immunol. 1979 May;122(5):1785–1790. [PubMed] [Google Scholar]
  2. Asherson G. L., Zembala M. Suppressor T cells in cell-mediated immunity. Br Med Bull. 1976 May;32(2):158–164. doi: 10.1093/oxfordjournals.bmb.a071349. [DOI] [PubMed] [Google Scholar]
  3. Chaturvedi U. C., Dalakoti H., Mathur A. Characterization of the cytotoxic factor produced in the spleen of dengue virus-infected mice. Immunology. 1980 Oct;41(2):387–392. [PMC free article] [PubMed] [Google Scholar]
  4. Chaturvedi U. C., Gulati L., Mathur A. Inhibition of E-rosette formation and phagocytosis by human blood leucocytes after treatment with the dengue virus-induced cytotoxic factor. Immunology. 1982 Apr;45(4):679–685. [PMC free article] [PubMed] [Google Scholar]
  5. Chaturvedi U. C., Mathur K. R., Gulati I., Mathur A. Target lymphoid cells for the cytotoxic factor produced in the spleen of dengue virus-infected mice. Immunol Lett. 1981 Apr;3(1):13–16. doi: 10.1016/0165-2478(81)90088-2. [DOI] [PubMed] [Google Scholar]
  6. Chaturvedi U. C., Nagar R., Mathur A. Effect of dengue virus infection on Fc-receptor functions of mouse macrophages. J Gen Virol. 1983 Nov;64(Pt 11):2399–2407. doi: 10.1099/0022-1317-64-11-2399. [DOI] [PubMed] [Google Scholar]
  7. Chaturvedi U. C., Tandon P., Mathur A. Effect of immunosuppression on dengue virus infection in mice. J Gen Virol. 1977 Sep;36(3):449–458. doi: 10.1099/0022-1317-36-3-449. [DOI] [PubMed] [Google Scholar]
  8. Cowing C., Schwartz B. D., Dickler H. B. Macrophage Ia antigens. I. macrophage populations differ in their expression of Ia antigens. J Immunol. 1978 Feb;120(2):378–384. [PubMed] [Google Scholar]
  9. Gulati L., Chaturvedi U. C., Mathur A. Characterization of the cytotoxin produced by macrophages in response to dengue virus-induced cytotoxic factor. Br J Exp Pathol. 1983 Apr;64(2):185–190. [PMC free article] [PubMed] [Google Scholar]
  10. Gulati L., Chaturvedi U. C., Mathur A. Dengue virus-induced cytotoxic factor induces macrophages to produce a cytotoxin. Immunology. 1983 May;49(1):121–130. [PMC free article] [PubMed] [Google Scholar]
  11. Gulati L., Chaturvedi U. C., Mathur A. Effect of dengue virus-induced macrophage cytotoxin on functions of human blood leucocytes. Indian J Med Res. 1984 Jun;79:709–715. [PubMed] [Google Scholar]
  12. Gulati L., Chaturvedi U. C., Mathur A. Plasma membrane-acting drugs inhibit the effect of dengue virus-induced cytotoxic factor. Ann Immunol (Paris) 1983 Mar-Apr;134C(2):227–235. doi: 10.1016/s0769-2625(83)80094-4. [DOI] [PubMed] [Google Scholar]
  13. Gulati L., Chaturvedi U. C., Mathur A. Production of dengue virus-induced macrophage cytotoxin in vivo. Br J Exp Pathol. 1986 Apr;67(2):269–277. [PMC free article] [PubMed] [Google Scholar]
  14. Morahan P. S., Connor J. R., Leary K. R. Viruses and the versatile macrophage. Br Med Bull. 1985 Jan;41(1):15–21. doi: 10.1093/oxfordjournals.bmb.a072017. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Shukla M. I., Chaturvedi U. C. Presence of I-region gene products on the cells and their products of the dengue virus-induced suppressor pathway. Br J Exp Pathol. 1986 Aug;67(4):563–569. [PMC free article] [PubMed] [Google Scholar]
  16. Sissons J. G., Borysiewicz L. K. Viral immunopathology. Br Med Bull. 1985 Jan;41(1):34–40. doi: 10.1093/oxfordjournals.bmb.a072021. [DOI] [PubMed] [Google Scholar]
  17. Takeda Y., Shimada S., Sugimoto M., Woo H. J., Higuchi M., Osawa T. Purification and characterization of a cytotoxic factor produced by a mouse macrophage hybridoma. Cell Immunol. 1985 Dec;96(2):277–289. doi: 10.1016/0008-8749(85)90360-0. [DOI] [PubMed] [Google Scholar]
  18. Waksman B. H. Cellular hypersensitivity and immunity: conceptual changes in last decade. Cell Immunol. 1979 Jan;42(1):155–169. doi: 10.1016/0008-8749(79)90229-6. [DOI] [PubMed] [Google Scholar]
  19. Ziegler H. K., Staffileno L. K., Wentworth P. Modulation of macrophage Ia-expression by lipopolysaccharide. I. Induction of Ia expression in vivo. J Immunol. 1984 Oct;133(4):1825–1835. [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES