Skip to main content
PMC home page
Immunology logoLink to Immunology
. 1985 Jun;55(2):241–247.

Transfer of specific immunosuppression of graft rejection using lymph from tolerant liver-grafted rats.

N Kamada
PMCID: PMC1453622  PMID: 3891594

Abstract

The effect on graft rejection of lymph from rats rendered tolerant of donor antigens by liver transplantation has been studied. Transfer, by daily intravenous injection, of lymph from PVG rats grafted with DA livers prolonged the survival of DA skin, kidney and heart grafts in normal PVG recipients. The effect was specific for the antigens of the liver donor. Suppression was short-term only; thus, after lymph injections were stopped, rejection occurred with a time course approximating a normal first-set reaction. The result suggests a reversible interference by materials in the tolerant lymph with early stages of sensitization of the recipients.

Full text

PDF
247

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Calne R. Y., Sells R. A., Pena J. R., Davis D. R., Millard P. R., Herbertson B. M., Binns R. M., Davies D. A. Induction of immunological tolerance by porcine liver allografts. Nature. 1969 Aug 2;223(5205):472–476. doi: 10.1038/223472a0. [DOI] [PubMed] [Google Scholar]
  2. Calne R. Y., White H. J., Yoffa D. E., Maginn R. R., Binns R. M., Samuel J. R., Molina V. P. Observations of orthotopic liver transplantation in the pig. Br Med J. 1967 May 20;2(5550):478–480. doi: 10.1136/bmj.2.5550.478. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Heron I. A technique for accessory cervical heart transplantation in rabbits and rats. Acta Pathol Microbiol Scand A. 1971;79(4):366–372. doi: 10.1111/j.1699-0463.1971.tb01833.x. [DOI] [PubMed] [Google Scholar]
  4. Houssin D., Gigou M., Franco D., Bismuth H., Charpentier B., Lang P., Martin E. Specific transplantation tolerance induced by spontaneously tolerated liver allograft in inbred strains of rats. Transplantation. 1980 May;29(5):418–419. doi: 10.1097/00007890-198005000-00015. [DOI] [PubMed] [Google Scholar]
  5. Kamada N., Brons G., Davies H. S. Fully allogeneic liver grafting in rats induces a state of systemic nonreactivity to donor transplantation antigens. Transplantation. 1980 May;29(5):429–431. doi: 10.1097/00007890-198005000-00021. [DOI] [PubMed] [Google Scholar]
  6. Kamada N., Davies H. S., Roser B. J. Fully allogeneic liver grafting and the induction of donor-specific unreactivity. Transplant Proc. 1981 Mar;13(1 Pt 2):837–841. [PubMed] [Google Scholar]
  7. Kamada N., Davies H. S., Roser B. Reversal of transplantation immunity by liver grafting. Nature. 1981 Aug 27;292(5826):840–842. doi: 10.1038/292840a0. [DOI] [PubMed] [Google Scholar]
  8. Kamada N., Davies H. S., Wight D., Culank L., Roser B. Liver transplantation in the rat. Biochemical and histological evidence of complete tolerance induction in non-rejector strains. Transplantation. 1983 Apr;35(4):304–311. [PubMed] [Google Scholar]
  9. Roser B., Ford W. L. Prolonged lymphocytopenia in the rat. the immunological consequences of lymphocyte depletion following injection of 185 W tungsten trioxide into the spleen of lymph nodes. Aust J Exp Biol Med Sci. 1972 Apr;50(2):185–198. [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES