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. 1987 Sep;62(1):113–118.

Ontogeny of ovine lymphocytes. III. An immunohistological study on the development of T lymphocytes in sheep fetal lymph nodes.

J F Maddox 1, C R Mackay 1, M R Brandon 1
PMCID: PMC1453718  PMID: 3308690

Abstract

The development of T lymphocytes in ovine fetal lymph nodes was studied immunohistologically using a panel of monoclonal antibodies. T lymphocyte subsets appeared within the ovine fetal lymph node in a specific sequence. SBU-T1- and SBU-T8-positive lymphocytes were seen at Day 47 of gestation. LCA, sIg, MHC I, MHC II, SBU-T6 and 46.66 antigens were also seen within the lymph node at this time. The first SBU-T4-positive cells were seen within the fetal lymph node at Day 50 of gestation, along with the first 20.96-, 25.69- and 38.38-positive cells. SBU-T19 lymphocytes appeared later in gestation, being present in fetal lymph nodes from Day 69 of gestation. The appearance and distribution of T and B cells in the developing lymph nodes of the ovine fetus is described and compared with the ontogeny of lymphocytes in the fetal thymus and spleen.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bofill M., Janossy G., Janossa M., Burford G. D., Seymour G. J., Wernet P., Kelemen E. Human B cell development. II. Subpopulations in the human fetus. J Immunol. 1985 Mar;134(3):1531–1538. [PubMed] [Google Scholar]
  2. Bélisle C., Sainte-Marie G. Tridimensional study of the deep cortex of the rat lymph node. I: Topography of the deep cortex. Anat Rec. 1981 Jan;199(1):45–59. doi: 10.1002/ar.1091990106. [DOI] [PubMed] [Google Scholar]
  3. Cahill R. N., Heron I., Poskitt D. C., Trnka Z. Lymphocyte recirculation in the sheep fetus. Ciba Found Symp. 1980;71:145–166. doi: 10.1002/9780470720547.ch9. [DOI] [PubMed] [Google Scholar]
  4. Cole G. J., Morris B. The lymphoid apparatus of the sheep: its growth, development and significance in immunologic reactions. Adv Vet Sci Comp Med. 1973;17:225–263. [PubMed] [Google Scholar]
  5. Fahey K. J., Morris B. Humoral immune responses in foetal sheep. Immunology. 1978 Oct;35(4):651–661. [PMC free article] [PubMed] [Google Scholar]
  6. Fahey K. J., Morris B. Lymphopoiesis and immune reactivity in the foetal lamb. Ser Haematol. 1974;7(4):548–567. [PubMed] [Google Scholar]
  7. Friedberg S. H., Weissman I. L. Lymphoid tissue architecture. II. Ontogeny of peripheral T and B cells in mice: evidence against Peyer's patches as the site of generation of B cells. J Immunol. 1974 Nov;113(5):1477–1492. [PubMed] [Google Scholar]
  8. Kovárù F., Stepánková R., Kruml J., Mandel L., Kenig E. Development of lymphatic and haemopoietic organs in germfree models. Folia Microbiol (Praha) 1979;24(1):32–43. doi: 10.1007/BF02927243. [DOI] [PubMed] [Google Scholar]
  9. Mackay C. R., Maddox J. F., Brandon M. R. Three distinct subpopulations of sheep T lymphocytes. Eur J Immunol. 1986 Jan;16(1):19–25. doi: 10.1002/eji.1830160105. [DOI] [PubMed] [Google Scholar]
  10. Maddox J. F., Mackay C. R., Brandon M. R. Four antigens expressed on most ovine cell types. Immunology. 1986 Dec;59(4):631–632. [PMC free article] [PubMed] [Google Scholar]
  11. Maddox J. F., Mackay C. R., Brandon M. R. Ontogeny of ovine lymphocytes. II. An immunohistological study on the development of T lymphocytes in the sheep fetal spleen. Immunology. 1987 Sep;62(1):107–112. [PMC free article] [PubMed] [Google Scholar]
  12. Markgraf R., von Gaudecker B., Müller-Hermelink H. K. The development of the human lymph node. Cell Tissue Res. 1982;225(2):387–413. doi: 10.1007/BF00214691. [DOI] [PubMed] [Google Scholar]
  13. Pearson L. D., Simpson-Morgan M. W., Morris B. Lymphopoiesis and lymphocyte recirculation in the sheep fetus. J Exp Med. 1976 Jan 1;143(1):167–186. doi: 10.1084/jem.143.1.167. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. SILVERSTEIN A. M., UHR J. W., KRANER K. L., LUKES R. J. Fetal response to antigenic stimulus. II. Antibody production by the fetal lamb. J Exp Med. 1963 May 1;117:799–812. doi: 10.1084/jem.117.5.799. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Tuboly S., Glávits R., Bucsek M. Stages in the development of the ovine immune system. Zentralbl Veterinarmed B. 1984 Mar;31(2):81–95. doi: 10.1111/j.1439-0450.1984.tb01285.x. [DOI] [PubMed] [Google Scholar]

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