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. 1986 Jan;57(1):111–114.

Cyclosporine affects the function of antigen-presenting cells.

A M Varey, B R Champion, A Cooke
PMCID: PMC1453899  PMID: 3484718

Abstract

The immunosuppressant drug cyclosporine (CsA) is known to affect T-cell function. We have studied the effect of CsA on the specific proliferative response of T-cell lines to antigen. In addition to blocking IL-2 release by specifically activated T-cell lines, CsA also affected the ability of irradiated spleen cells to present preprocessed antigen to T-cell lines. Irradiated spleen cells pulsed with antigen for 2 hr were able to stimulate a proliferative response in T-cell lines. Following a 2-hr pulse with CsA, antigen presentation by these irradiated spleen cells was reduced significantly, suggesting that CsA not only affects T cells, but also affects the function of antigen-presenting cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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