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. 1987 Nov;62(3):363–371.

Modulation of granulocyte functions by bacterial exotoxin and endotoxins.

K D Bremm 1, W König 1, M Thelestam 1, J E Alouf 1
PMCID: PMC1454132  PMID: 2889665

Abstract

The modulation of granulocyte functions by bacterial exotoxins (Streptolysin O, alveolysin, theta toxin) and endotoxins from salmonella and lipid A is described here. Incubation of polymorphonuclear granulocytes with thiol-activated toxins resulted in an increased leukotriene generation. Toxin-pretreated PMNs revealed an increased omega oxidation of LTB4, which may explain why toxin-stimulated cells release more LTC4 than LTB4. Furthermore, toxin-pretreated PMNs showed a decreased leukotriene generation on subsequent stimulation with the Ca-ionophore A 23187 or opsonized zymosan.

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Selected References

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