Abstract
Repeated exposure of high IgE-responder BN rats to an aerosol of ovalbumin (OVA) induced tolerance which was specific both for the antigen and the IgE antibody class. Radiotracer studies with 125I-OVA indicated that inhaled antigen doses in the low microgram range were tolerogenic, the bulk of the inhaled antigen being distributed 2:1 between the gastro-intestinal and respiratory tracts. Subsequent gastric intubation studies showed that the gastric component did not contribute to tolerance induction, suggesting that antigenic stimulation of the respiratory mucosa was central to this process.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Carswell F., Oliver J. The respiratory response in sensitized rats to aerosol challenge. Immunology. 1978 Mar;34(3):465–470. [PMC free article] [PubMed] [Google Scholar]
- Fox P. C., Siraganian R. P. IgE antibody suppression following aerosol exposure to antigens. Immunology. 1981 Jun;43(2):227–234. [PMC free article] [PubMed] [Google Scholar]
- Holt P. G., Batty J. E., Turner K. J. Inhibition of specific IgE responses in mice by pre-exposure to inhaled antigen. Immunology. 1981 Mar;42(3):409–417. [PMC free article] [PubMed] [Google Scholar]
- Holt P. G., Leivers S. Tolerance induction via antigen inhalation: isotype specificity, stability, and involvement of suppressor T cells. Int Arch Allergy Appl Immunol. 1982;67(2):155–160. doi: 10.1159/000233007. [DOI] [PubMed] [Google Scholar]
- Holt P. G., Rose A. H., Batty J. E., Turner K. J. Induction of adjuvant-independent IgE responses in inbred mice: primary, secondary, and persistent IgE responses to ovalbumin and ovomucoid. Int Arch Allergy Appl Immunol. 1981;65(1):42–50. doi: 10.1159/000232736. [DOI] [PubMed] [Google Scholar]
- Ishii A., Matsuhashi T., Miyamoto J., Sasa M. Production of homocytotropic antibody in guinea pigs inhalated with an extract of the house dust mite, Dermatophagoides farinae. Jpn J Exp Med. 1973 Feb;43(1):25–32. [PubMed] [Google Scholar]
- Jarrett E. E. Activation of IgE regulatory mechanisms by transmucosal absorption of antigen. Lancet. 1977 Jul 30;2(8031):223–225. doi: 10.1016/s0140-6736(77)92837-9. [DOI] [PubMed] [Google Scholar]
- Miller S. D., Hanson D. G. Inhibition of specific immune responses by feeding protein antigens. IV. Evidence for tolerance and specific active suppression of cell-mediated immune responses to ovalbumin. J Immunol. 1979 Nov;123(5):2344–2350. [PubMed] [Google Scholar]
- O'Donnell I. J., Mitchell G. F. An investigation of the allergens of Ascaris lumbricoides using a radioallergosorbent test (RAST) and sera of naturally infected humans: comparison with an allergen for mice identified by a passive cutaneous anaphylaxis test. Aust J Biol Sci. 1978 Oct;31(5):459–487. doi: 10.1071/bi9780459. [DOI] [PubMed] [Google Scholar]
- Piechuta H., Smith M. E., Share N. N., Holme G. The respiratory response of sensitized rats to challenge with antigen aerosols. Immunology. 1979 Oct;38(2):385–392. [PMC free article] [PubMed] [Google Scholar]
- Price P., Bell R. G. The toxicity of inactivated bacteria and endotoxin in mice suffering from protein malnutrition. J Reticuloendothel Soc. 1975 Oct;18(4):230–243. [PubMed] [Google Scholar]
- Thomas H. C., Parrott M. V. The induction of tolerance to a soluble protein antigen by oral administration. Immunology. 1974 Oct;27(4):631–639. [PMC free article] [PubMed] [Google Scholar]
- Van Hout C. A., Johnson H. G. Synthesis of rat IgE by aerosol immunization. J Immunol. 1972 Mar;108(3):834–836. [PubMed] [Google Scholar]
- Willoughby J. B., Willoughby W. F. In vivo responses to inhaled proteins. I. Quantitative analysis of antigen uptake, fate, and immunogenicity in a rabbit model system. J Immunol. 1977 Dec;119(6):2137–2146. [PubMed] [Google Scholar]