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. 1970 Apr;18(4):537–543.

Catabolism of γG-globulin and myeloma proteins of the subclasses γG1 and γG2 in a healthy volunteer

J Watkins, D E H Tee
PMCID: PMC1455487  PMID: 4986976

Abstract

The catabolism of myeloma proteins of the γG-subclasses γG1 and γG2 were measured in a healthy volunteer and contrasted with that of γG-globulin preparations containing all four subclasses and isolated from various sources.

The γG2 protein had a biological half-life of 24 days, showing no evidence of catabolic heterogeneity as measured over a period of 7 weeks. In contrast, the γG1 protein showed some catabolic heterogeneity, the half-life increasing from 15 to 19 days over the same period. It is possible that molecules of γG1-globulins may exist in different conformational forms.

The catabolism of whole γG-globulin is heterogeneous. This can be substantially explained in terms of the resultant catabolic pattern of mixtures of γG1- and γG2-globulin molecules.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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