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. 1970 Jan;18(1):39–47.

Antigenic stimulation of bone marrow colony forming cells

I. Effect of antigens on normal bone marrow cells in vitro

T A McNeill
PMCID: PMC1455511  PMID: 4903985

Abstract

The incorporation of some antigens such as bacterial endotoxin, heterologous erythrocytes and bacterial flagellin preparations can enhance the formation of colonies in cultures of normal mouse bone marrow or foetal liver cells in vitro. Other antigens such as foreign serum proteins and haemocyanin are inactive. This effect depends on the reaction of antigen with a component of normal mouse serum.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADA G. L., NOSSAL G. J., PYE J., ABBOT A. ANTIGENS IN IMMUNITY. I. PREPARATION AND PROPERTIES OF FLAGELLAR ANTIGENS FROM SALMONELLA ADELAIDE. Aust J Exp Biol Med Sci. 1964 Jun;42:267–282. [PubMed] [Google Scholar]
  2. Ada G. L., Lang P. G., Plymin G. Antigen in tissues. V. Effect of endotoxin on the fate of, and on the immun response to, serum albumin and to albumin-antibody complexes. Immunology. 1968 Jun;14(6):825–836. [PMC free article] [PubMed] [Google Scholar]
  3. Bradley T. R., Metcalf D. The growth of mouse bone marrow cells in vitro. Aust J Exp Biol Med Sci. 1966 Jun;44(3):287–299. doi: 10.1038/icb.1966.28. [DOI] [PubMed] [Google Scholar]
  4. Bradley T. R., Sumner M. A. Stimulation of mouse bone marrow colony growth in vitro by conditioned medium. Aust J Exp Biol Med Sci. 1968 Oct;46(5):607–618. doi: 10.1038/icb.1968.167. [DOI] [PubMed] [Google Scholar]
  5. Ichikawa Y., Pluznik D. H., Sachs L. In vitro control of the development of macrophage and granulocyte colonies. Proc Natl Acad Sci U S A. 1966 Aug;56(2):488–495. doi: 10.1073/pnas.56.2.488. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. McNeill T. A. Antigenic stimulation of bone marrow colony forming cells. II. Properties of a serum factor responsible for antigenic enhancement of colonies. Immunology. 1970 Jan;18(1):49–59. [PMC free article] [PubMed] [Google Scholar]
  7. Metcalf D., Foster R. Bone marrow colony-stimulating activity of serum from mice with viral-induced leukemia. J Natl Cancer Inst. 1967 Dec;39(6):1235–1245. [PubMed] [Google Scholar]
  8. Metcalf D. Potentiation of bone marrow colony growth in vitro by the addition of lymphoid or bone marrow cells. J Cell Physiol. 1968 Aug;72(1):9–19. doi: 10.1002/jcp.1040720104. [DOI] [PubMed] [Google Scholar]
  9. Pluznik D. H., Sachs L. The cloning of normal "mast" cells in tissue culture. J Cell Physiol. 1965 Dec;66(3):319–324. doi: 10.1002/jcp.1030660309. [DOI] [PubMed] [Google Scholar]

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