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. 1970 Mar;18(3):379–386.

Development of Coombs positive haemolytic anaemia in NZB mice injected with Freund's complete adjuvant

Jane I Morton, B V Siegel
PMCID: PMC1455560  PMID: 5442216

Abstract

Intraperitoneal injection of young adult NZB mice with Freund's complete adjuvant emulsion, alone or incorporating BALB/c mouse erythrocytes, resulted in accelerated direct Coombs conversion and development of splenomegaly. Incorporation of adjuvant with NZB erythrocytes caused an accelerated reactivity in some animals, but in others resulted in a delayed Coombs conversion. In contrast, positive Coombs tests failed to develop at all in NZB mice injected with a Freund's complete adjuvant preparation containing ten times the usual amount of Mycobacterium. These observations might be explained in part by the relative influences of adjuvancy and of antigenic competition on the availability of precursor cells capable of responding to autoantigenic stimulation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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