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. 1970 Jul;19(1):55–63.

Experimental autoimmune encephalomyelitis*

Digestion of basic protein of human myelin with cyanogen bromide and trypsin

P R Carnegie, T A McPherson, G S M Robson
PMCID: PMC1455612  PMID: 4098596

Abstract

From a cyanogen bromide digest of the encephalitogenic basic protein of human brain a polypeptide—derived from the N-terminal end of the protein—was isolated and shown to induce experimental autoimmune encephalomyelitis. At low doses this peptide induced typical histological lesions unaccompanied by clinical symptoms and humoral antibody. Digestion of the protein with trypsin did not destroy its encephalitogenic activity. The basic protein of human myelin contains more than one encephalitogenic determinant.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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